PMID- 26544935
OWN - NLM
STAT- MEDLINE
DCOM- 20160225
LR  - 20221109
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 163
IP  - 4
DP  - 2015 Nov 5
TI  - Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.
PG  - 811-28
LID - S0092-8674(15)01400-2 [pii]
LID - 10.1016/j.cell.2015.10.044 [doi]
AB  - Two decades of studies in multiple model organisms have established the Hippo 
      pathway as a key regulator of organ size and tissue homeostasis. By inhibiting 
      YAP and TAZ transcription co-activators, the Hippo pathway regulates cell 
      proliferation, apoptosis, and stemness in response to a wide range of 
      extracellular and intracellular signals, including cell-cell contact, cell 
      polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular 
      energy status. Dysregulation of the Hippo pathway exerts a significant impact on 
      cancer development. Further investigation of the functions and regulatory 
      mechanisms of this pathway will help uncovering the mystery of organ size control 
      and identify new targets for cancer treatment.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Yu, Fa-Xing
AU  - Yu FX
AD  - Children's Hospital and Institutes of Biomedical Sciences, Fudan University, 
      Shanghai 200032, China. Electronic address: fxyu@fudan.edu.cn.
FAU - Zhao, Bin
AU  - Zhao B
AD  - Life Sciences Institute and Innovation Center for Cell Signaling Network, 
      Zhejiang University, Hangzhou, Zhejiang 310058, China.
FAU - Guan, Kun-Liang
AU  - Guan KL
AD  - Department of Pharmacology and Moores Cancer Center, University of California, 
      San Diego, La Jolla, CA 92093, USA. Electronic address: kuguan@ucsd.edu.
LA  - eng
GR  - P50 DK039255/DK/NIDDK NIH HHS/United States
GR  - DE015964/DE/NIDCR NIH HHS/United States
GR  - EY022611/EY/NEI NIH HHS/United States
GR  - R01 EY022611/EY/NEI NIH HHS/United States
GR  - R01 CA132809/CA/NCI NIH HHS/United States
GR  - CA196878/CA/NCI NIH HHS/United States
GR  - GM51586/GM/NIGMS NIH HHS/United States
GR  - R35 CA196878/CA/NCI NIH HHS/United States
GR  - R01 GM051586/GM/NIGMS NIH HHS/United States
GR  - CA132809/CA/NCI NIH HHS/United States
GR  - R01 CA108941/CA/NCI NIH HHS/United States
GR  - R01 DE015964/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Physiological Phenomena
MH  - Homeostasis
MH  - Humans
MH  - Neoplasms/*metabolism
MH  - *Organ Size
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - *Signal Transduction
PMC - PMC4638384
MID - NIHMS734261
EDAT- 2015/11/07 06:00
MHDA- 2016/02/26 06:00
PMCR- 2016/11/05
CRDT- 2015/11/07 06:00
PHST- 2015/06/22 00:00 [received]
PHST- 2015/11/07 06:00 [entrez]
PHST- 2015/11/07 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
PHST- 2016/11/05 00:00 [pmc-release]
AID - S0092-8674(15)01400-2 [pii]
AID - 10.1016/j.cell.2015.10.044 [doi]
PST - ppublish
SO  - Cell. 2015 Nov 5;163(4):811-28. doi: 10.1016/j.cell.2015.10.044.