PMID- 26590417
OWN - NLM
STAT- MEDLINE
DCOM- 20160327
LR  - 20230207
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 163
IP  - 5
DP  - 2015 Nov 19
TI  - Establishment and Dysfunction of the Blood-Brain Barrier.
PG  - 1064-1078
LID - S0092-8674(15)01423-3 [pii]
LID - 10.1016/j.cell.2015.10.067 [doi]
AB  - Structural and functional brain connectivity, synaptic activity, and information 
      processing require highly coordinated signal transduction between different cell 
      types within the neurovascular unit and intact blood-brain barrier (BBB) 
      functions. Here, we examine the mechanisms regulating the formation and 
      maintenance of the BBB and functions of BBB-associated cell types. Furthermore, 
      we discuss the growing evidence associating BBB breakdown with the pathogenesis 
      of inherited monogenic neurological disorders and complex multifactorial 
      diseases, including Alzheimer's disease.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Zhao, Zhen
AU  - Zhao Z
AD  - Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, 
      Keck School of Medicine of the University of Southern California, Los Angeles, CA 
      90089, USA.
FAU - Nelson, Amy R
AU  - Nelson AR
AD  - Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, 
      Keck School of Medicine of the University of Southern California, Los Angeles, CA 
      90089, USA.
FAU - Betsholtz, Christer
AU  - Betsholtz C
AD  - Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, 
      75185 Uppsala, Sweden.
FAU - Zlokovic, Berislav V
AU  - Zlokovic BV
AD  - Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, 
      Keck School of Medicine of the University of Southern California, Los Angeles, CA 
      90089, USA. Electronic address: zlokovic@usc.edu.
LA  - eng
GR  - R01 AG039452/AG/NIA NIH HHS/United States
GR  - R01 NS034467/NS/NINDS NIH HHS/United States
GR  - R01NS090904/NS/NINDS NIH HHS/United States
GR  - RF1 AG039452/AG/NIA NIH HHS/United States
GR  - R01 NS090904/NS/NINDS NIH HHS/United States
GR  - P50 AG005142/AG/NIA NIH HHS/United States
GR  - R01NS034467/NS/NINDS NIH HHS/United States
GR  - R01AG023084/AG/NIA NIH HHS/United States
GR  - R01 AG023084/AG/NIA NIH HHS/United States
GR  - R01AG039452/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Membrane Transport Proteins)
SB  - IM
MH  - Animals
MH  - Astrocytes/metabolism
MH  - Blood-Brain Barrier/cytology/physiology/*physiopathology
MH  - Endothelial Cells/metabolism
MH  - Humans
MH  - Membrane Transport Proteins/metabolism
MH  - Nervous System Diseases/genetics/pathology/*physiopathology
MH  - Pericytes/cytology
PMC - PMC4655822
MID - NIHMS734996
EDAT- 2015/11/23 06:00
MHDA- 2016/03/28 06:00
PMCR- 2016/11/19
CRDT- 2015/11/23 06:00
PHST- 2015/08/11 00:00 [received]
PHST- 2015/11/23 06:00 [entrez]
PHST- 2015/11/23 06:00 [pubmed]
PHST- 2016/03/28 06:00 [medline]
PHST- 2016/11/19 00:00 [pmc-release]
AID - S0092-8674(15)01423-3 [pii]
AID - 10.1016/j.cell.2015.10.067 [doi]
PST - ppublish
SO  - Cell. 2015 Nov 19;163(5):1064-1078. doi: 10.1016/j.cell.2015.10.067.