PMID- 26688694
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1773-2247 (Print)
IS  - 1773-2247 (Linking)
VI  - 30
IP  - Pt B
DP  - 2015 Dec 1
TI  - POLYMERIC BIOMATERIALS AND NANOMEDICINES.
PG  - 318-330
AB  - This overview intends to demonstrate the close relationship between the design of 
      smart biomaterials and water-soluble polymer-drug conjugates. First, the 
      discovery and systematic studies of hydrogels based on crosslinked 
      poly(meth)acrylic acid esters and substituted amides is described. Then, the 
      lessons learned for the design of water-soluble polymers as drug carriers are 
      highlighted. The current state-of-the-art in water-soluble, mainly 
      poly[N-(2-hydroxypropyl)methacylamide (HPMA), polymer-drug conjugates is shown 
      including the design of backbone degradable HPMA copolymer carriers. In the 
      second part, the modern design of hybrid hydrogels focuses on the self-assembly 
      of hybrid copolymers composed from the synthetic part (backbone) and 
      biorecognizable grafts (coiled-coil forming peptides or morpholino 
      oligonucleotides) is shown. The research of self-assembling hydrogels inspired 
      the invention and design of drug-free macromolecular therapeutics - a new 
      paradigm in drug delivery where crosslinking of non-internalizating CD20 
      receptors results in apoptosis in vitro and in vivo. The latter is mediated by 
      biorecognition of complementary motifs; no low molecular weight drug is needed.
FAU - Yang, Jiyuan
AU  - Yang J
AD  - Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 
      Salt Lake City, Utah 84112, USA.
FAU - Kopecek, Jindrich
AU  - Kopecek J
AD  - Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 
      Salt Lake City, Utah 84112, USA ; Department of Bioengineering, University of 
      Utah, Salt Lake City, Utah 84112, USA.
LA  - eng
GR  - R01 EB005288/EB/NIBIB NIH HHS/United States
GR  - R01 GM095606/GM/NIGMS NIH HHS/United States
GR  - R03 TW006260/TW/FIC NIH HHS/United States
GR  - R41 CA156933/CA/NCI NIH HHS/United States
GR  - R01 CA132831/CA/NCI NIH HHS/United States
GR  - R42 CA156933/CA/NCI NIH HHS/United States
GR  - R01 GM069847/GM/NIGMS NIH HHS/United States
GR  - R01 CA051578/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - France
TA  - J Drug Deliv Sci Technol
JT  - Journal of drug delivery science and technology
JID - 101214432
PMC - PMC4681002
MID - NIHMS693394
OTO - NOTNLM
OT  - Cancer
OT  - Drug-free macromolecular therapeutics
OT  - Hydrogels
OT  - Nanomedicines
OT  - Polymer-drug conjugates
OT  - Self-assembly of macromolecules
EDAT- 2015/12/22 06:00
MHDA- 2015/12/22 06:01
PMCR- 2016/12/01
CRDT- 2015/12/22 06:00
PHST- 2015/12/22 06:00 [entrez]
PHST- 2015/12/22 06:00 [pubmed]
PHST- 2015/12/22 06:01 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - 10.1016/j.jddst.2015.05.012 [doi]
PST - ppublish
SO  - J Drug Deliv Sci Technol. 2015 Dec 1;30(Pt B):318-330. doi: 
      10.1016/j.jddst.2015.05.012.