PMID- 26962241 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200123 IS - 1465-3621 (Electronic) IS - 0368-2811 (Linking) VI - 46 IP - 6 DP - 2016 Jun TI - Patient age was an independent predictor of cancer-specific survival in male patients with upper tract urothelial carcinoma treated by radical nephroureterectomy. PG - 554-559 LID - hyw028 [pii] LID - 10.1093/jjco/hyw028 [doi] AB - OBJECTIVE: We hypothesized that there may be a prognostic difference in age between the genders and evaluated the influence of gender-adjusted age on prognosis in upper tract urothelial carcinoma patients. METHODS: A total of 839 patients with upper tract urothelial carcinoma from a retrospective multi-institutional cohort were included. The patients were divided into four groups consisting of males (N = 610) and females (N = 229) according to age ((i) <60 years, (ii) 60-69.9 years, (iii) 70-79.9 years and (iv) >/=80 years), and we evaluated the associations of patient age and gender with clinicopathological features and oncological outcomes following radical nephroureterectomy. The median follow-up duration was 34 months. RESULTS: Disease recurrence occurred in 249 patients and 192 patients died of upper tract urothelial carcinoma. The 3-year cancer-specific survival rates were (i) 84.3%, (ii) 80.2%, (iii) 77.1% and (iv) 71.5% in the entire patient population (P = 0.001); (i) 84.5%, (ii) 81.1%, (iii) 76.8% and (iv) 69.7% in males (P = 0.010); and (i) 83.3%, (ii) 76.9%, (iii) 77.7% and (iv) 72.9% in females (P = 0.287), respectively. No significant differences between disease recurrence and age were found in the male or female population. In multivariate analysis, older age was an independent predictor of cancer-specific survival, in addition to advanced pT stage, the presence of lymphovascular invasion and lymph node involvement in males. In contrast, age was not associated with cancer-specific survival in females, while high grade, advanced pT stage, the presence of lymph node involvement and multifocal tumor were independent predictors. CONCLUSION: The results indicate that gender-adjusted age might be a new prognostic factor in upper tract urothelial carcinoma patients. CI - (c) The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. FAU - Kobayashi, Hiroaki AU - Kobayashi H AD - Department of Urology, Keio University School of Medicine, Tokyo Department of Urology, Kyosai Tachikawa Hospital, Tokyo. FAU - Kikuchi, Eiji AU - Kikuchi E AD - Department of Urology, Keio University School of Medicine, Tokyo eiji-k@kb3.so-net.ne.jp. FAU - Tanaka, Nobuyuki AU - Tanaka N AD - Department of Urology, Saitama City Hospital, Saitama Department of Urology, National Hospital Organization, Saitama Hospital, Saitama. FAU - Shirotake, Suguru AU - Shirotake S AD - Department of Urology, Keio University School of Medicine, Tokyo Department of Urology, International Medical Center-Comprehensive Cancer Center, Saitama Medical University, Saitama. FAU - Miyazaki, Yasumasa AU - Miyazaki Y AD - Department of Urology, Keio University School of Medicine, Tokyo Department of Urology, Ogikubo Hospital, Tokyo. FAU - Ide, Hiroki AU - Ide H AD - Department of Urology, Inagi Municipal Hospital, Tokyo Department of Urology, Musashino Yohwakai Hospital, Tokyo. FAU - Obata, Jun AU - Obata J AD - Department of Urology, Keio University School of Medicine, Tokyo Department of Urology, National Hospital Organization, Tochigi Medical Center, Tochigi. FAU - Hoshino, Katsura AU - Hoshino K AD - Department of Urology, Keio University School of Medicine, Tokyo Department of Urology, Saiseikai Yokohamashi Tobu Hospital, Kanagawa. FAU - Matsumoto, Kazuhiro AU - Matsumoto K AD - Department of Urology, Keio University School of Medicine, Tokyo Department of Urology, Tokyo Saiseikai Central Hospital, Tokyo. FAU - Kaneko, Gou AU - Kaneko G AD - Department of Urology, Keio University School of Medicine, Tokyo Department of Urology, Kawasaki Municipal Hospital, Kanagawa. FAU - Hagiwara, Masayuki AU - Hagiwara M AD - Department of Urology, Keio University School of Medicine, Tokyo Department of Urology, Tokyo Dental College Ichikawa General Hospital, Chiba. FAU - Kosaka, Takeo AU - Kosaka T AD - Department of Urology, Keio University School of Medicine, Tokyo Department of Urology, Irumagawa Hospital, Saitama, Japan. FAU - Oyama, Masafumi AU - Oyama M AD - Department of Urology, International Medical Center-Comprehensive Cancer Center, Saitama Medical University, Saitama. FAU - Nakajima, Yosuke AU - Nakajima Y AD - Department of Urology, Saiseikai Yokohamashi Tobu Hospital, Kanagawa. FAU - Oya, Mototsugu AU - Oya M AD - Department of Urology, Keio University School of Medicine, Tokyo. LA - eng PT - Journal Article DEP - 20160309 PL - England TA - Jpn J Clin Oncol JT - Japanese journal of clinical oncology JID - 0313225 OTO - NOTNLM OT - age OT - gender OT - radical nephroureterectomy OT - upper urinary tract OT - urothelial carcinoma EDAT- 2016/03/11 06:00 MHDA- 2016/03/11 06:01 CRDT- 2016/03/11 06:00 PHST- 2016/03/11 06:00 [entrez] PHST- 2016/03/11 06:00 [pubmed] PHST- 2016/03/11 06:01 [medline] AID - hyw028 [pii] AID - 10.1093/jjco/hyw028 [doi] PST - ppublish SO - Jpn J Clin Oncol. 2016 Jun;46(6):554-559. doi: 10.1093/jjco/hyw028. Epub 2016 Mar 9.