PMID- 2708412
OWN - NLM
STAT- MEDLINE
DCOM- 19890526
LR  - 20071114
IS  - 0021-9304 (Print)
IS  - 0021-9304 (Linking)
VI  - 23
IP  - 2
DP  - 1989 Feb
TI  - Brain biocompatibility of a biodegradable, controlled-release polymer in rats.
PG  - 253-66
AB  - We report the biocompatibility in the rat brain of a controlled-release, 
      biodegradable polymer, the polyanhydride 
      poly-[bis(p-carboxyphenoxy)propane-sebacic acid] copolymer (PCPP-SA) in a 20:80 
      formulation. The biodegradable polyanhydride can be used for drug delivery 
      directly into the brain, circumventing the difficulties posed by the blood-brain 
      barrier and avoiding the consequences of having to administer toxic doses 
      systematically to reach therapeutic doses in the central nervous system. The 
      tissue reaction in the presence of PCPP-SA was compared to that seen with other 
      standard neurosurgical implants. Fifty-six adult Sprague-Dawley rats were 
      assigned to one of seven groups and underwent bilateral frontal lobe implantation 
      of PCPP-SA (42 hemispheres), Surgicel (oxidized regenerated cellulose) (35 
      hemispheres), or Gelfoam (absorbable gelatin sponge) (35 hemispheres). None of 
      the animals showed any behavioral changes or neurological deficits suggestive of 
      either systemic or localized toxicity from the biodegradable polyanhydride, all 
      surviving to the scheduled data of sacrifice. PCPP-SA evoked a well localized 
      inflammatory reaction, comparable to that of Surgicel, which resolved as the 
      PCPP-SA polymer degraded over five weeks. The biodegradable polyanhydride has 
      been shown in this study to be nontoxic and biocompatible in the rat brain, when 
      compared to standard neurosurgical implants.
FAU - Tamargo, R J
AU  - Tamargo RJ
AD  - Department of Neurological Surgery, Johns Hopkins University School of Medicine, 
      Baltimore, Maryland 21205.
FAU - Epstein, J I
AU  - Epstein JI
FAU - Reinhard, C S
AU  - Reinhard CS
FAU - Chasin, M
AU  - Chasin M
FAU - Brem, H
AU  - Brem H
LA  - eng
GR  - NS01058-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biomed Mater Res
JT  - Journal of biomedical materials research
JID - 0112726
RN  - 0 (Biocompatible Materials)
RN  - 0 (Drug Implants)
RN  - 0 (Polymers)
SB  - IM
MH  - Animals
MH  - *Biocompatible Materials/adverse effects
MH  - Biodegradation, Environmental
MH  - Brain/*metabolism
MH  - Drug Implants/adverse effects/*metabolism
MH  - Inflammation/etiology/pathology
MH  - Male
MH  - *Polymers/adverse effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Time Factors
EDAT- 1989/02/01 00:00
MHDA- 1989/02/01 00:01
CRDT- 1989/02/01 00:00
PHST- 1989/02/01 00:00 [pubmed]
PHST- 1989/02/01 00:01 [medline]
PHST- 1989/02/01 00:00 [entrez]
AID - 10.1002/jbm.820230209 [doi]
PST - ppublish
SO  - J Biomed Mater Res. 1989 Feb;23(2):253-66. doi: 10.1002/jbm.820230209.