PMID- 27501451
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20180515
IS  - 1530-8995 (Electronic)
IS  - 1081-0706 (Linking)
VI  - 32
DP  - 2016 Oct 6
TI  - The Heidelberg Screen for Pattern Mutants of Drosophila: A Personal Account.
PG  - 1-46
AB  - In large-scale mutagenesis screens performed in 1979-1980 at the EMBL in 
      Heidelberg, we isolated mutations affecting the pattern or structure of the 
      larval cuticle in Drosophila. The 600 mutants we characterized could be assigned 
      to 120 genes and represent the majority of such genes in the genome. These 
      mutants subsequently provided a rich resource for understanding many fundamental 
      developmental processes, such as the transcriptional hierarchies controlling 
      segmentation, the establishment of cell states by signaling pathways, and the 
      differentiation of epithelial cells. Most of the Heidelberg genes are now 
      molecularly known, and many of them are conserved in other animals, including 
      humans. Although the screens were initially driven entirely by curiosity, the 
      mutants now serve as models for many human diseases. In this review, we describe 
      the rationale of the screening procedures and provide a classification of the 
      genes on the basis of their initial phenotypes and the subsequent molecular 
      analyses.
FAU - Wieschaus, Eric
AU  - Wieschaus E
AD  - Department of Molecular Biology, Princeton University, Princeton, New Jersey 
      08544; email: efw@princeton.edu.
FAU - Nusslein-Volhard, Christiane
AU  - Nusslein-Volhard C
AD  - Max-Planck-Institut fur Entwicklungsbiologie, 72076 Tubingen, Germany; email: 
      cnv@tuebingen.mpg.de.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160803
PL  - United States
TA  - Annu Rev Cell Dev Biol
JT  - Annual review of cell and developmental biology
JID - 9600627
SB  - IM
MH  - Animals
MH  - Drosophila/*genetics
MH  - Genes, Insect
MH  - *Genetic Testing
MH  - Mutagenesis/genetics
MH  - Mutation/*genetics
MH  - Signal Transduction/genetics
OTO - NOTNLM
OT  - Drosophila
OT  - autobiography
OT  - embryonic lethal mutations
OT  - larval cuticle
OT  - pattern formation
OT  - saturation screens
EDAT- 2016/08/09 06:00
MHDA- 2017/12/23 06:00
CRDT- 2016/08/09 06:00
PHST- 2016/08/09 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
PHST- 2016/08/09 06:00 [entrez]
AID - 10.1146/annurev-cellbio-113015-023138 [doi]
PST - ppublish
SO  - Annu Rev Cell Dev Biol. 2016 Oct 6;32:1-46. doi: 
      10.1146/annurev-cellbio-113015-023138. Epub 2016 Aug 3.