PMID- 27581568
OWN - NLM
STAT- MEDLINE
DCOM- 20170829
LR  - 20230603
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Print)
IS  - 0022-3751 (Linking)
VI  - 594
IP  - 17
DP  - 2016 Sep 1
TI  - Wnt pathway regulation of intestinal stem cells.
PG  - 4837-47
LID - 10.1113/JP271754 [doi]
AB  - Wnt signalling is involved in multiple aspects of embryonic development and adult 
      tissue homeostasis, notably via controlling cellular proliferation and 
      differentiation. Wnt signalling is subject to stringent positive and negative 
      regulation to promote proper development and homeostasis yet avoid aberrant 
      growth. Such multi-layer regulation includes post-translational modification and 
      processing of Wnt proteins themselves, R-spondin (Rspo) amplification of Wnt 
      signalling, diverse receptor families, and intracellular and extracellular 
      antagonists and destruction and transcription complexes. In the gastrointestinal 
      tract, Wnt signalling is crucial for development and renewal of the intestinal 
      epithelium. Intestinal stem cells (ISCs) undergo symmetric division and neutral 
      drift dynamics to renew the intestinal epithelium. Sources of Wnts and Wnt 
      amplifers such as R-spondins are beginning to be elucidated as well as their 
      functional contribution to intestinal homeostasis. In this review we focus on 
      regulation of ISCs and intestinal homeostasis by the Wnt/Rspo pathway, the 
      potential cellular sources of Wnt signalling regulators and highlight potential 
      future areas of study.
CI  - (c) 2016 The Authors. The Journal of Physiology (c) 2016 The Physiological Society.
FAU - Mah, Amanda T
AU  - Mah AT
AD  - Department of Medicine, Stanford University School of Medicine, Stanford, CA, 
      94305, USA.
FAU - Yan, Kelley S
AU  - Yan KS
AD  - Department of Medicine, Stanford University School of Medicine, Stanford, CA, 
      94305, USA.
FAU - Kuo, Calvin J
AU  - Kuo CJ
AD  - Department of Medicine, Stanford University School of Medicine, Stanford, CA, 
      94305, USA.
LA  - eng
GR  - U01 CA151920/CA/NCI NIH HHS/United States
GR  - U01 CA176299/CA/NCI NIH HHS/United States
GR  - U24 DK085532/DK/NIDDK NIH HHS/United States
GR  - U01 DK085532/DK/NIDDK NIH HHS/United States
GR  - K08 DK096048/DK/NIDDK NIH HHS/United States
GR  - U01 DE025188/DE/NIDCR NIH HHS/United States
GR  - U19 AI116484/AI/NIAID NIH HHS/United States
GR  - U01 DK085527/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20160616
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
SB  - IM
MH  - Animals
MH  - Intestines/*cytology/physiology
MH  - Regeneration
MH  - Stem Cells/*physiology
MH  - *Wnt Signaling Pathway
PMC - PMC5009769
EDAT- 2016/09/02 06:00
MHDA- 2017/08/30 06:00
PMCR- 2017/09/01
CRDT- 2016/09/02 06:00
PHST- 2015/10/16 00:00 [received]
PHST- 2016/02/08 00:00 [accepted]
PHST- 2016/09/02 06:00 [entrez]
PHST- 2016/09/02 06:00 [pubmed]
PHST- 2017/08/30 06:00 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - TJP7268 [pii]
AID - 10.1113/JP271754 [doi]
PST - ppublish
SO  - J Physiol. 2016 Sep 1;594(17):4837-47. doi: 10.1113/JP271754. Epub 2016 Jun 16.