PMID- 2779414
OWN - NLM
STAT- MEDLINE
DCOM- 19891025
LR  - 20190824
IS  - 0740-3194 (Print)
IS  - 0740-3194 (Linking)
VI  - 11
IP  - 2
DP  - 1989 Aug
TI  - A liposomal MRI contrast agent: phosphatidylethanolamine-DTPA.
PG  - 236-43
AB  - The chelating agent, diethylenetriaminepentaacetic acid (DTPA), was attached via 
      one -COOH group to the amino headgroup of phosphatidylethanolamine to produce a 
      phospholipid which is also a powerful chelating agent. It readily assembles into 
      the walls of lipid bilayer structures as a liposome-associated carrier of cations 
      for MR contrast or radioisotope studies. Freeze-etch electron microscopy showed 
      that phosphatidylethanolamine-DTPA formed satisfactory sonicated vesicles when 
      mixed with natural phospholipids at up to 50 wt%. The resultant structures with 
      bound gadolinium effectively shortened T1 and T2 of surrounding water protons. 
      When sonicated liposomes bearing chelating agent with bound 111In3+ were injected 
      intravenously into rats, uptake was primarily by liver and spleen. By 24 h 
      postinjection there was biliary excretion of this material. 
      Phosphatidylethanolamine-DTPA may have some general utility as an amphiphilic 
      liposomal chelating agent for polyvalent cations.
FAU - Grant, C W
AU  - Grant CW
AD  - Department of Biochemistry, University of Western Ontario, London, Canada.
FAU - Karlik, S
AU  - Karlik S
FAU - Florio, E
AU  - Florio E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
RN  - 0 (Chelating Agents)
RN  - 0 (Contrast Media)
RN  - 0 (Liposomes)
RN  - 0 (Phosphatidylethanolamines)
RN  - 3026-45-7 (1,2-dipalmitoyl-3-phosphatidylethanolamine)
RN  - 7A314HQM0I (Pentetic Acid)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Animals
MH  - *Chelating Agents/pharmacokinetics
MH  - *Contrast Media/pharmacokinetics
MH  - Evaluation Studies as Topic
MH  - Gadolinium/pharmacokinetics
MH  - Liposomes/*administration & dosage/pharmacokinetics
MH  - Magnetic Resonance Imaging
MH  - *Pentetic Acid/pharmacokinetics
MH  - *Phosphatidylethanolamines/administration & dosage/pharmacokinetics
MH  - Rats
EDAT- 1989/08/01 00:00
MHDA- 1989/08/01 00:01
CRDT- 1989/08/01 00:00
PHST- 1989/08/01 00:00 [pubmed]
PHST- 1989/08/01 00:01 [medline]
PHST- 1989/08/01 00:00 [entrez]
AID - 10.1002/mrm.1910110211 [doi]
PST - ppublish
SO  - Magn Reson Med. 1989 Aug;11(2):236-43. doi: 10.1002/mrm.1910110211.