PMID- 2783273
OWN - NLM
STAT- MEDLINE
DCOM- 19890123
LR  - 20211001
IS  - 0361-803X (Print)
IS  - 0361-803X (Linking)
VI  - 152
IP  - 1
DP  - 1989 Jan
TI  - The diagnosis of splenic lymphoma by MR imaging: value of superparamagnetic iron 
      oxide.
PG  - 175-80
AB  - This study was designed to evaluate superparamagnetic iron oxide (AMI-25) as a 
      contrast agent for MR to distinguish normal spleens from those diffusely 
      infiltrated by lymphoma. As diffuse splenic involvement lacks visible 
      tumor-tissue boundaries, signal-intensity measurements of spleens were used as a 
      diagnostic criterion in 33 patients (lymphoma, n = 8; benign splenomegaly, n = 5; 
      normal subjects, n = 20). Unenhanced MR images were insensitive (four of eight 
      patients) and nonspecific (20 of 25 patients) in the diagnosis of lymphoma. After 
      injection of superparamagnetic iron oxide (40 mumol Fe/kg), lymphomatous spleens 
      showed a significantly higher signal intensity (p less than .05) than did normal 
      spleens or spleens enlarged by benign disease (hepatic cirrhosis, n = 4; 
      spherocytosis, n = 1). Changes in splenic MR signal intensity unambiguously 
      identified eight of eight lymphomatous spleens and 25 of 25 normal or enlarged 
      spleens that did not contain lymphoma. Phagocytosis of superparamagnetic iron 
      oxide in lymphomatous spleens is reduced because of diffuse displacement of 
      splenic macrophages by lymphoma cells and/or by immunologic suppression of 
      macrophage activity. Our results suggest that superparamagnetic iron oxide 
      (AMI-25) can improve the accuracy of MR imaging in the diagnosis of splenic 
      lymphoma. With further development, this noninvasive technique may reduce the 
      need for diagnostic splenectomy in lymphoma patients.
FAU - Weissleder, R
AU  - Weissleder R
AD  - Department of Radiology, Massachusetts General Hospital, Boston.
FAU - Elizondo, G
AU  - Elizondo G
FAU - Stark, D D
AU  - Stark DD
FAU - Hahn, P F
AU  - Hahn PF
FAU - Marfil, J
AU  - Marfil J
FAU - Gonzalez, J F
AU  - Gonzalez JF
FAU - Saini, S
AU  - Saini S
FAU - Todd, L E
AU  - Todd LE
FAU - Ferrucci, J T
AU  - Ferrucci JT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - AJR Am J Roentgenol
JT  - AJR. American journal of roentgenology
JID - 7708173
RN  - 0 (Contrast Media)
RN  - 0 (Oxides)
RN  - E1UOL152H7 (Iron)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - *Contrast Media
MH  - Evaluation Studies as Topic
MH  - Ferrosoferric Oxide
MH  - Hodgkin Disease/diagnosis
MH  - Humans
MH  - *Iron
MH  - Lymphoma/*diagnosis
MH  - Lymphoma, Non-Hodgkin/diagnosis
MH  - *Magnetic Resonance Imaging
MH  - *Oxides
MH  - Splenic Neoplasms/*diagnosis
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.2214/ajr.152.1.175 [doi]
PST - ppublish
SO  - AJR Am J Roentgenol. 1989 Jan;152(1):175-80. doi: 10.2214/ajr.152.1.175.