PMID- 2808524
OWN - NLM
STAT- MEDLINE
DCOM- 19891205
LR  - 20190508
IS  - 0021-9525 (Print)
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Linking)
VI  - 109
IP  - 5
DP  - 1989 Nov
TI  - The complete sequence of Drosophila alpha-spectrin: conservation of structural 
      domains between alpha-spectrins and alpha-actinin.
PG  - 2197-205
AB  - We report the complete sequence of Drosophila alpha-spectrin and show that it is 
      similar to vertebrate nonerythroid spectrins. As in vertebrates, the alpha 
      subunit consists of two large domains of repetitive sequence (segments 1-9 and 
      11-19) separated by a short nonrepetitive sequence (segment 10). The 106-residue 
      repetitive segments are defined by a consensus sequence of 54 residues. Chicken 
      alpha-spectrin (Wasenius, V.-M., M. Saraste, P. Salven, M. Eramaa, L. Holm, V.-P. 
      Lehto. 1989. J. Cell Biol. 108:79-93) shares 50 of these consensus positions. 
      Through comparison of spectrin and alpha-actinin sequences, we describe a second 
      lineage of spectrin segments (20 and 21) that differs from the 106-residue 
      segments by an 8-residue insertion and by lack of many of the consensus residues. 
      We present a model of spectrin evolution in which the repetitive lineage of 
      spectrin segments and the nonrepetitive lineage of segments found in spectrin and 
      alpha-actinin arose by separate multiplication events.
FAU - Dubreuil, R R
AU  - Dubreuil RR
AD  - Department of Cellular and Developmental Biology, Harvard University, Cambridge, 
      Massachusetts 02138.
FAU - Byers, T J
AU  - Byers TJ
FAU - Sillman, A L
AU  - Sillman AL
FAU - Bar-Zvi, D
AU  - Bar-Zvi D
FAU - Goldstein, L S
AU  - Goldstein LS
FAU - Branton, D
AU  - Branton D
LA  - eng
SI  - GENBANK/M26400
GR  - GM39686/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 11003-00-2 (Actinin)
RN  - 12634-43-4 (Spectrin)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Actinin/*genetics
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chickens
MH  - Cloning, Molecular
MH  - DNA/genetics
MH  - Dictyostelium/genetics
MH  - Drosophila/*genetics
MH  - Molecular Sequence Data
MH  - Repetitive Sequences, Nucleic Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Spectrin/*genetics
PMC - PMC2115856
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
PMCR- 1990/05/01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
PHST- 1990/05/01 00:00 [pmc-release]
AID - 90037215 [pii]
AID - 10.1083/jcb.109.5.2197 [doi]
PST - ppublish
SO  - J Cell Biol. 1989 Nov;109(5):2197-205. doi: 10.1083/jcb.109.5.2197.