PMID- 2827004
OWN - NLM
STAT- MEDLINE
DCOM- 19880210
LR  - 20210526
IS  - 0270-7306 (Print)
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Linking)
VI  - 8
IP  - 1
DP  - 1988 Jan
TI  - Identification of a common ecotropic viral integration site, Evi-1, in the DNA of 
      AKXD murine myeloid tumors.
PG  - 301-8
AB  - AKXD-23 recombinant inbred mice develop myeloid tumors at a high frequency, 
      unlike other AKXD recombinant inbred strains which develop B-cell lymphomas, 
      T-cell lymphomas, or both. AKXD-23 myeloid tumors are monoclonal, and their DNA 
      contains somatically acquired proviruses, suggesting that they are retrovirally 
      induced. We identified a common site of ecotropic proviral integration that is 
      present in the DNA of all AKXD-23 myeloid tumors that were analyzed and in the 
      DNA of all myeloid tumors that occur in AKXD strains other than AKXD-23. We 
      designated this locus Evi-1 (ecotropic viral integration site 1). Rearrangements 
      in the Evi-1 locus were also detected in the DNA of a number of myeloid tumors 
      and myeloid cell lines isolated from strains other than AKXD. In contrast, few 
      Evi-1 rearrangements were detected in the DNA of T- or B-cell tumors. Evi-1 may 
      thus identify a new proto-oncogene locus that is involved in myeloid disease.
FAU - Mucenski, M L
AU  - Mucenski ML
AD  - Mammalian Genetics Laboratory, National Cancer Institute, Frederick, Maryland 
      21701.
FAU - Taylor, B A
AU  - Taylor BA
FAU - Ihle, J N
AU  - Ihle JN
FAU - Hartley, J W
AU  - Hartley JW
FAU - Morse, H C 3rd
AU  - Morse HC 3rd
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Copeland, N G
AU  - Copeland NG
LA  - eng
GR  - CA-33093/CA/NCI NIH HHS/United States
GR  - CA-37283/CA/NCI NIH HHS/United States
GR  - N01-CO-23909/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (DNA, Neoplasm)
RN  - 0 (DNA, Viral)
RN  - EC 3.1.21.- (DNA Restriction Enzymes)
SB  - IM
MH  - Animals
MH  - *Cell Transformation, Viral
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA Restriction Enzymes
MH  - DNA, Neoplasm/*genetics
MH  - DNA, Viral/*genetics
MH  - Leukemia, Experimental/*genetics
MH  - Lymphoma/genetics
MH  - Mice/*genetics
MH  - *Proto-Oncogenes
MH  - Recombination, Genetic
MH  - Retroviridae/*genetics
PMC - PMC363121
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
PMCR- 1988/01/01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PHST- 1988/01/01 00:00 [pmc-release]
AID - 10.1128/mcb.8.1.301-308.1988 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1988 Jan;8(1):301-8. doi: 10.1128/mcb.8.1.301-308.1988.