PMID- 2828590
OWN - NLM
STAT- MEDLINE
DCOM- 19880310
LR  - 20181130
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 153
IP  - 4
DP  - 1987 Dec
TI  - Prognostic factors in breast cancer: immunohistochemical staining for SP1 and 
      NCRC 11 related to survival, tumour epidermal growth factor receptor and 
      oestrogen receptor status.
PG  - 325-31
AB  - It has been proposed that intense immunohistochemical staining using the 
      monoclonal antibody NCRC 11 is indicative of a better prognosis in breast cancer, 
      and that expression of pregnancy specific glycoprotein (SP1) and epidermal growth 
      factor receptors (EGFR) are poor prognosis indicators. In order to evaluate the 
      significance of staining for NCRC 11 to prognosis and to these other variables, 
      we studied two series of breast cancer patients. In one series (n = 93), staining 
      with NCRC 11 and for SP1 was correlated with prognosis: in neither case was there 
      any overall relationship between staining and survival. However, when the 
      patients were stratified by tumour histological (Bloom's) grade, SP1 expression 
      was associated with a poorer prognosis in grade II tumours (p less than 0.025). 
      In a further series (n = 94), NCRC 11 staining was carried out and fresh tumour 
      samples were assayed biochemically for oestrogen receptor (OER) and EGFR. NCRC 11 
      showed a negative correlation with EGFR status (p = less than 0.05) but no 
      significant association with OER status. Thus despite our demonstration of a 
      negative correlation with an indicator of poorer prognosis, we were unable to 
      demonstrate any direct relationship between staining with NCRC 11 and survival.
FAU - Wright, C
AU  - Wright C
AD  - Department of Pathology, University of Newcastle upon Tyne, U.K.
FAU - Angus, B
AU  - Angus B
FAU - Napier, J
AU  - Napier J
FAU - Wetherall, M
AU  - Wetherall M
FAU - Udagawa, Y
AU  - Udagawa Y
FAU - Sainsbury, J R
AU  - Sainsbury JR
FAU - Johnston, S
AU  - Johnston S
FAU - Carpenter, F
AU  - Carpenter F
FAU - Horne, C H
AU  - Horne CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Pregnancy Proteins)
RN  - 0 (Pregnancy-Specific beta 1-Glycoproteins)
RN  - 0 (Receptors, Estrogen)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - *Antibodies, Monoclonal
MH  - Breast Neoplasms/*analysis/mortality
MH  - Carcinoma, Intraductal, Noninfiltrating/analysis
MH  - ErbB Receptors/*analysis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Pregnancy Proteins/*analysis
MH  - Pregnancy-Specific beta 1-Glycoproteins/*analysis
MH  - Prognosis
MH  - Receptors, Estrogen/*analysis
MH  - Time Factors
EDAT- 1987/12/01 00:00
MHDA- 1987/12/01 00:01
CRDT- 1987/12/01 00:00
PHST- 1987/12/01 00:00 [pubmed]
PHST- 1987/12/01 00:01 [medline]
PHST- 1987/12/01 00:00 [entrez]
AID - 10.1002/path.1711530406 [doi]
PST - ppublish
SO  - J Pathol. 1987 Dec;153(4):325-31. doi: 10.1002/path.1711530406.