PMID- 2828930
OWN - NLM
STAT- MEDLINE
DCOM- 19880303
LR  - 20190824
IS  - 0161-5890 (Print)
IS  - 0161-5890 (Linking)
VI  - 24
IP  - 12
DP  - 1987 Dec
TI  - Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr 
      detected only on CD4 positive T blasts.
PG  - 1281-90
AB  - Mouse monoclonal antibodies (MAbs) have been prepared against rat T cell blasts. 
      One MAb called MRC OX-40 recognized an antigen that differed from any previously 
      described in that its expression was detected only on T blasts that also 
      expressed the CD4 antigen. The OX-40 MAb did not detect an activation determinant 
      of CD2 or CD4 molecules but recognized a distinct chain of mol. wt 50,000. The 
      OX-40 MAb augmented T cell proliferation at late stages on in vitro responses. 
      Other MAbs without obvious counterparts in other species were MRC OX-48 and MRC 
      OX-49,50 which recognized cell surface molecules of mol. wts of about 95,000 and 
      90,000, respectively. The OX-48 antigen was not expressed on resting lymphocytes 
      but was found on a subset of T and B blasts and also on other leucocytes. The 
      OX-49,50 antigen was found on most haemopoietic cells but was expressed at 
      greatly increased levels after lymphocyte activation and this was also the case 
      for MRC OX-47 antigen which is of unknown Mr. The MRC OX-39 MAb was found to bind 
      the rat IL-2 receptor; expression of this antigen was detected on thymic 
      dendritic cells as well as on T blasts. The phenotype of rat T blasts compared to 
      resting cells was also examined and changes in expression of L-CA, Thy-1, OX-2 
      and CD8 antigens were seen in addition to the changes found with the above MAbs.
FAU - Paterson, D J
AU  - Paterson DJ
AD  - MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of 
      Oxford, U.K.
FAU - Jefferies, W A
AU  - Jefferies WA
FAU - Green, J R
AU  - Green JR
FAU - Brandon, M R
AU  - Brandon MR
FAU - Corthesy, P
AU  - Corthesy P
FAU - Puklavec, M
AU  - Puklavec M
FAU - Williams, A F
AU  - Williams AF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Surface)
RN  - 0 (Tumor Necrosis Factor Receptor Superfamily, Member 7)
RN  - 11028-71-0 (Concanavalin A)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/immunology
MH  - Antigens, Surface/*analysis
MH  - Cell Division
MH  - Concanavalin A/pharmacology
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Immunoenzyme Techniques
MH  - *Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Weight
MH  - Rats
MH  - Rats, Inbred Strains
MH  - T-Lymphocytes/*immunology
MH  - Tumor Necrosis Factor Receptor Superfamily, Member 7
EDAT- 1987/12/01 00:00
MHDA- 1987/12/01 00:01
CRDT- 1987/12/01 00:00
PHST- 1987/12/01 00:00 [pubmed]
PHST- 1987/12/01 00:01 [medline]
PHST- 1987/12/01 00:00 [entrez]
AID - 10.1016/0161-5890(87)90122-2 [doi]
PST - ppublish
SO  - Mol Immunol. 1987 Dec;24(12):1281-90. doi: 10.1016/0161-5890(87)90122-2.