PMID- 2832761
OWN - NLM
STAT- MEDLINE
DCOM- 19880427
LR  - 20131121
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 332
IP  - 6162
DP  - 1988 Mar 24
TI  - The GLI gene is a member of the Kruppel family of zinc finger proteins.
PG  - 371-4
AB  - Many studies have established that a select subset of normal cellular genes are 
      altered in cancer by point mutations, translocations or gene amplification. 
      However, the vast majority of genetic changes that occur in neoplastic cells have 
      not yet been identified. In an attempt to identify some of these other genetic 
      changes, we have recently isolated a gene, GLI, by virtue of its amplification in 
      a human glioblastoma. Subsequently, GLI was found to be amplified in other human 
      glioblastomas (ref. 3 and unpublished data). To understand better the role of GLI 
      in human neoplasia, we have now cloned the GLI complementary DNA (cDNA) and 
      determined its nucleotide sequence. Analysis of the predicted translation product 
      reveals that it contains five repeats of a DNA binding consensus sequence (zinc 
      finger) originally described in Xenopus Transcription Factor III A (TFIIIA). 
      Furthermore, these zinc fingers contain sequence elements that suggest the GLI 
      gene product is a member of the recently described Kruppel family of zinc finger 
      proteins. Additional experiments demonstrate that GLI is an evolutionarily 
      conserved gene that is expressed in embryonal carcinoma cells but not in most 
      adult tissues. The link between the developmentally important Kruppel family of 
      genes and GLI is interesting considering the similarities between developing 
      embryonic and neoplastic tissue.
FAU - Kinzler, K W
AU  - Kinzler KW
AD  - Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, 
      MD 21205.
FAU - Ruppert, J M
AU  - Ruppert JM
FAU - Bigner, S H
AU  - Bigner SH
FAU - Vogelstein, B
AU  - Vogelstein B
LA  - eng
SI  - GENBANK/X07384
GR  - CA-09243/CA/NCI NIH HHS/United States
GR  - CA-43722/CA/NCI NIH HHS/United States
GR  - GM-07184/GM/NIGMS NIH HHS/United States
GR  - etc.
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Metalloproteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (oncofetal antigens)
RN  - 0 (zinc-binding protein)
RN  - 9007-49-2 (DNA)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens, Neoplasm/genetics
MH  - Base Sequence
MH  - Carrier Proteins/*genetics
MH  - Cell Line
MH  - DNA/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Drosophila melanogaster/genetics
MH  - Genes
MH  - Glioblastoma/genetics
MH  - Humans
MH  - Metalloproteins/*genetics
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/*genetics
MH  - Sequence Homology, Nucleic Acid
MH  - Teratoma/genetics
MH  - Vertebrates/genetics
MH  - Zinc
EDAT- 1988/03/24 00:00
MHDA- 1988/03/24 00:01
CRDT- 1988/03/24 00:00
PHST- 1988/03/24 00:00 [pubmed]
PHST- 1988/03/24 00:01 [medline]
PHST- 1988/03/24 00:00 [entrez]
AID - 10.1038/332371a0 [doi]
PST - ppublish
SO  - Nature. 1988 Mar 24;332(6162):371-4. doi: 10.1038/332371a0.