PMID- 2841109
OWN - NLM
STAT- MEDLINE
DCOM- 19880916
LR  - 20220511
IS  - 0261-4189 (Print)
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Linking)
VI  - 7
IP  - 4
DP  - 1988 Apr
TI  - Progressive loss of DNA sequences from terminal chromosome deficiencies in 
      Drosophila melanogaster.
PG  - 1081-6
AB  - Terminal deficiencies at the tip of the X chromosome can be induced at a high 
      frequency (0.2-0.3%) by irradiating Drosophila females carrying a homozygous 
      mutator (mu-2) with low doses of X-rays. These terminal deficiencies are 
      unstable, since over a period of 3 1/2 years DNA sequences were lost from their 
      distal ends at a rate of 75 bp per generation, presumably due to the absence of a 
      complete wild-type telomeric structure. Breakpoints of these deletions in the 5' 
      upstream regulatory region of the yellow gene, giving rise to a mosaic cuticle 
      pigmentation pattern typical of the y2 type, were used to define the location of 
      tissue-specific cis-acting regulatory elements that are required for body, wing 
      or bristle pigmentation.
FAU - Biessmann, H
AU  - Biessmann H
AD  - Developmental Biology Center, University of California, Irvine 92717.
FAU - Mason, J M
AU  - Mason JM
LA  - eng
GR  - GM 32154/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 9007-49-2 (DNA)
RN  - EC 3.1.21.- (DNA Restriction Enzymes)
SB  - IM
MH  - Animals
MH  - Chromosomes/physiology
MH  - Crosses, Genetic
MH  - DNA/*genetics/radiation effects
MH  - DNA Restriction Enzymes
MH  - Drosophila melanogaster/*genetics
MH  - Female
MH  - Genes, Regulator
MH  - Male
MH  - *Mutation
MH  - X-Rays
PMC - PMC454439
EDAT- 1988/04/01 00:00
MHDA- 1988/04/01 00:01
PMCR- 1989/04/01
CRDT- 1988/04/01 00:00
PHST- 1988/04/01 00:00 [pubmed]
PHST- 1988/04/01 00:01 [medline]
PHST- 1988/04/01 00:00 [entrez]
PHST- 1989/04/01 00:00 [pmc-release]
AID - 10.1002/j.1460-2075.1988.tb02916.x [doi]
PST - ppublish
SO  - EMBO J. 1988 Apr;7(4):1081-6. doi: 10.1002/j.1460-2075.1988.tb02916.x.