PMID- 2884106
OWN - NLM
STAT- MEDLINE
DCOM- 19870716
LR  - 20220511
IS  - 0261-4189 (Print)
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Linking)
VI  - 6
IP  - 3
DP  - 1987 Mar
TI  - Characterization and localization of the even-skipped protein of Drosophila.
PG  - 749-59
AB  - On the basis of homeo box cross-homology we have isolated the pair-rule gene 
      even-skipped (eve) of Drosophila. The eve transcription unit appears to be less 
      than 1.5 kb in length, and encodes a single mRNA of approximately 1.4 kb. The 
      nucleotide sequence of genomic and cDNA clones indicates that the eve protein is 
      composed of 376 amino acid residues, and that its homeo domain shares only 
      approximately 50% amino acid identity with the homeo domains of previously 
      characterized genes. Using antibodies raised against a beta-galactosidase fusion 
      protein we show that the eve protein is distributed in a series of seven 
      transverse stripes at the cellular blastoderm stage, and is localized primarily 
      within the nuclear regions of those embryonic cells that express the gene. After 
      gastrulation, seven weakly stained stripes of eve expression appear, resulting in 
      a transient pattern that consists of a total of 14 evenly spaced stripes. Both 
      the original and new stripes gradually disappear during germ band elongation. A 
      second expression pattern emerges during neurogenesis, whereby eve protein is 
      detected in discrete subsets of neurons in each of the ventral ganglia.
FAU - Frasch, M
AU  - Frasch M
FAU - Hoey, T
AU  - Hoey T
FAU - Rushlow, C
AU  - Rushlow C
FAU - Doyle, H
AU  - Doyle H
FAU - Levine, M
AU  - Levine M
LA  - eng
SI  - GENBANK/X05138
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Bacterial Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 0 (eve protein, Drosophila)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Bacterial Proteins
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA/analysis
MH  - Drosophila/embryology/*genetics
MH  - *Drosophila Proteins
MH  - Embryo, Nonmammalian/physiology
MH  - *Genes, Fungal
MH  - Genes, Homeobox
MH  - *Homeodomain Proteins
MH  - Mutation
MH  - Nervous System/embryology
MH  - Proteins/*genetics
MH  - RNA, Messenger/genetics
MH  - *Transcription Factors
MH  - Transcription, Genetic
PMC - PMC553460
EDAT- 1987/03/01 00:00
MHDA- 1987/03/01 00:01
PMCR- 1988/03/01
CRDT- 1987/03/01 00:00
PHST- 1987/03/01 00:00 [pubmed]
PHST- 1987/03/01 00:01 [medline]
PHST- 1987/03/01 00:00 [entrez]
PHST- 1988/03/01 00:00 [pmc-release]
AID - 10.1002/j.1460-2075.1987.tb04817.x [doi]
PST - ppublish
SO  - EMBO J. 1987 Mar;6(3):749-59. doi: 10.1002/j.1460-2075.1987.tb04817.x.