PMID- 28964625
OWN - NLM
STAT- MEDLINE
DCOM- 20171101
LR  - 20220330
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Linking)
VI  - 42
IP  - 11
DP  - 2017 Nov
TI  - Regulation of the Hippo Pathway Transcription Factor TEAD.
PG  - 862-872
LID - S0968-0004(17)30170-6 [pii]
LID - 10.1016/j.tibs.2017.09.003 [doi]
AB  - The TEAD transcription factor family is best known for transcriptional output of 
      the Hippo signaling pathway and has been implicated in processes such as 
      development, cell growth and proliferation, tissue homeostasis, and regeneration. 
      Our understanding of the functional importance of TEADs has increased 
      dramatically since its initial discovery three decades ago. The majority of our 
      knowledge of TEADs is in the context of Hippo signaling as nuclear DNA-binding 
      proteins passively activated by Yes-associated protein (YAP) and transcriptional 
      activator with PDZ-binding domain (TAZ), transcription coactivators downstream of 
      the Hippo pathway. However, recent studies suggest that TEAD itself is actively 
      regulated. Here, we highlight evidence demonstrating Hippo-independent regulation 
      of TEADs and the potential impacts these studies may have on new cancer 
      therapeutics.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Lin, Kimberly C
AU  - Lin KC
AD  - Department of Pharmacology and Moores Cancer Center, University of California San 
      Diego, La Jolla, CA 92093, USA.
FAU - Park, Hyun Woo
AU  - Park HW
AD  - Department of Biochemistry, College of Life Science and Biotechnology, Yonsei 
      University, Seoul 120-749, Republic of Korea.
FAU - Guan, Kun-Liang
AU  - Guan KL
AD  - Department of Pharmacology and Moores Cancer Center, University of California San 
      Diego, La Jolla, CA 92093, USA. Electronic address: kuguan@ucsd.edu.
LA  - eng
GR  - R01 DE015964/DE/NIDCR NIH HHS/United States
GR  - R01 GM051586/GM/NIGMS NIH HHS/United States
GR  - R35 CA196878/CA/NCI NIH HHS/United States
GR  - T32 GM007752/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170927
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (TEA Domain Transcription Factors)
RN  - 0 (TEAD1 protein, human)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Hippo Signaling Pathway
MH  - Humans
MH  - Nuclear Proteins/genetics/metabolism
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - *Signal Transduction
MH  - TEA Domain Transcription Factors
MH  - Transcription Factors/genetics/*metabolism
PMC - PMC5735856
MID - NIHMS906282
OTO - NOTNLM
OT  - Hippo
OT  - TEAD
OT  - YAP/TAZ
OT  - cancer
OT  - cytoplasmic-nuclear shuttling
EDAT- 2017/10/02 06:00
MHDA- 2017/11/02 06:00
PMCR- 2018/11/01
CRDT- 2017/10/02 06:00
PHST- 2017/08/08 00:00 [received]
PHST- 2017/09/06 00:00 [revised]
PHST- 2017/09/07 00:00 [accepted]
PHST- 2017/10/02 06:00 [pubmed]
PHST- 2017/11/02 06:00 [medline]
PHST- 2017/10/02 06:00 [entrez]
PHST- 2018/11/01 00:00 [pmc-release]
AID - S0968-0004(17)30170-6 [pii]
AID - 10.1016/j.tibs.2017.09.003 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 2017 Nov;42(11):862-872. doi: 10.1016/j.tibs.2017.09.003. 
      Epub 2017 Sep 27.