PMID- 28985214
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20220409
IS  - 1546-170X (Electronic)
IS  - 1078-8956 (Linking)
VI  - 23
IP  - 10
DP  - 2017 Oct 6
TI  - Cancer stem cells revisited.
PG  - 1124-1134
LID - 10.1038/nm.4409 [doi]
AB  - The cancer stem cell (CSC) concept was proposed four decades ago, and states that 
      tumor growth, analogous to the renewal of healthy tissues, is fueled by small 
      numbers of dedicated stem cells. It has gradually become clear that many tumors 
      harbor CSCs in dedicated niches, and yet their identification and eradication has 
      not been as obvious as was initially hoped. Recently developed lineage-tracing 
      and cell-ablation strategies have provided insights into CSC plasticity, 
      quiescence, renewal, and therapeutic response. Here we discuss new developments 
      in the CSC field in relationship to changing insights into how normal stem cells 
      maintain healthy tissues. Expectations in the field have become more realistic, 
      and now, the first successes of therapies based on the CSC concept are emerging.
FAU - Batlle, Eduard
AU  - Batlle E
AD  - Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of 
      Science and Technology, Barcelona, Spain.
AD  - Institucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona, Spain.
AD  - CiberONC, Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), 
      Barcelona, Spain.
FAU - Clevers, Hans
AU  - Clevers H
AD  - Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University 
      Medical Center Utrecht and Princess Maxima Center, Utrecht, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
SB  - IM
MH  - Adult Stem Cells/*physiology
MH  - Animals
MH  - Cell Lineage
MH  - Cell Plasticity/*physiology
MH  - Cell Self Renewal/*physiology
MH  - *Drug Resistance, Neoplasm
MH  - Epithelial-Mesenchymal Transition
MH  - Humans
MH  - Neoplasms/*drug therapy
MH  - Neoplastic Stem Cells/metabolism/*physiology
MH  - Stem Cells/physiology
MH  - Tumor Microenvironment
EDAT- 2017/10/07 06:00
MHDA- 2017/10/17 06:00
CRDT- 2017/10/07 06:00
PHST- 2017/01/23 00:00 [received]
PHST- 2017/08/23 00:00 [accepted]
PHST- 2017/10/07 06:00 [entrez]
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
AID - nm.4409 [pii]
AID - 10.1038/nm.4409 [doi]
PST - ppublish
SO  - Nat Med. 2017 Oct 6;23(10):1124-1134. doi: 10.1038/nm.4409.