PMID- 2911585
OWN - NLM
STAT- MEDLINE
DCOM- 19890214
LR  - 20220129
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 86
IP  - 1
DP  - 1989 Jan
TI  - Heme oxygenase is the major 32-kDa stress protein induced in human skin 
      fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.
PG  - 99-103
AB  - We have shown that UVA (320-380 nm) radiation, hydrogen peroxide, and sodium 
      arsenite induce a stress protein of approximately 32 kDa in human skin 
      fibroblasts. The synthesis and cloning of cDNA from arsenite-induced mRNA 
      populations have now allowed us to unequivocally identify the 32-kDa protein as 
      heme oxygenase. By mRNA analysis we have shown that the heme oxygenase gene is 
      also induced in cultured human skin fibroblasts by UVA radiation, hydrogen 
      peroxide, cadmium chloride, iodoacetamide, and menadione. The known antioxidant 
      properties of heme catabolites taken together with the observation of a high 
      level of induction of the enzyme in cells from an organ not involved in 
      hemoglobin breakdown strongly supports the proposal that the induction of heme 
      oxygenase may be a general response to oxidant stress and constitutes an 
      important cellular defense mechanism against oxidative damage.
FAU - Keyse, S M
AU  - Keyse SM
AD  - Swiss Institute for Experimental Cancer Research, Epalinges.
FAU - Tyrrell, R M
AU  - Tyrrell RM
LA  - eng
SI  - GENBANK/M23041
SI  - GENBANK/M23042
GR  - 12053/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Arsenites)
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Sodium Compounds)
RN  - 48OVY2OC72 (sodium arsenite)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.- (Mixed Function Oxygenases)
RN  - EC 1.14.14.18 (HMOX1 protein, human)
RN  - EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Amino Acid Sequence
MH  - Arsenic/*pharmacology
MH  - *Arsenites
MH  - Base Sequence
MH  - Cell Line
MH  - Enzyme Induction
MH  - Fibroblasts/enzymology
MH  - Genes
MH  - Heat-Shock Proteins/biosynthesis/*genetics
MH  - Heme Oxygenase (Decyclizing)/biosynthesis/*genetics
MH  - Heme Oxygenase-1/biosynthesis/*genetics
MH  - Humans
MH  - Hydrogen Peroxide/*pharmacology
MH  - Kinetics
MH  - Mixed Function Oxygenases/*genetics
MH  - Molecular Sequence Data
MH  - Molecular Weight
MH  - Skin/drug effects/*enzymology/radiation effects
MH  - *Sodium Compounds
MH  - *Ultraviolet Rays
PMC - PMC286411
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
PMCR- 1989/07/01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
PHST- 1989/07/01 00:00 [pmc-release]
AID - 10.1073/pnas.86.1.99 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1989 Jan;86(1):99-103. doi: 10.1073/pnas.86.1.99.