PMID- 2924997
OWN - NLM
STAT- MEDLINE
DCOM- 19890508
LR  - 20190721
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 132
IP  - 2
DP  - 1989 Apr
TI  - Genetic control of sexually dimorphic axon morphology in Drosophila sensory 
      neurons.
PG  - 448-57
AB  - The mechanism by which orderly axonal projections are formed during development 
      remains an important and largely unsolved problem in neurobiology. It may be 
      possible to examine the control of axon growth in Drosophila and take advantage 
      of genetic tools to better understand the phenomenon. We show here that some 
      gustatory axons in Drosophila are sexually dimorphic and that genes involved in 
      sex determination control the anatomy of these axons. Both males and females 
      possess gustatory receptors on their legs but males possess more of these 
      receptors than females. More significantly, the axons of the male receptors 
      usually cross the midline and they never do so in females, indicating a central 
      zone of bilateral input in the male but not in the female nervous system. In 
      chromosomal females, expressing a tra or Sxl mutation, the gustatory system is 
      transformed toward the male phenotype. Mutant XX adults resemble normal males 
      externally, because they have more gustatory receptors, and internally, because 
      their axons cross the midline. Gynandromorphs show that the sex of the sensory 
      neuron, and apparently not the central nervous system, controls the growth of the 
      axons. We conclude that the anatomical site of control for this dimorphism is the 
      gustatory neurons.
FAU - Possidente, D R
AU  - Possidente DR
AD  - Department of Biology, State University of New York, Albany 12222.
FAU - Murphey, R K
AU  - Murphey RK
LA  - eng
GR  - NS-15571/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
SB  - IM
MH  - Animals
MH  - Axons/*ultrastructure
MH  - Drosophila/*genetics/ultrastructure
MH  - Extremities/innervation
MH  - Female
MH  - Genotype
MH  - Male
MH  - Mutation
MH  - Neurons, Afferent/*ultrastructure
MH  - Phenotype
MH  - *Sex Characteristics
MH  - Sex Differentiation
MH  - Taste Buds
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
AID - 0012-1606(89)90241-8 [pii]
AID - 10.1016/0012-1606(89)90241-8 [doi]
PST - ppublish
SO  - Dev Biol. 1989 Apr;132(2):448-57. doi: 10.1016/0012-1606(89)90241-8.