PMID- 2928549
OWN - NLM
STAT- MEDLINE
DCOM- 19890428
LR  - 20151119
IS  - 0033-8419 (Print)
IS  - 0033-8419 (Linking)
VI  - 171
IP  - 1
DP  - 1989 Apr
TI  - Liposomal Gd-DTPA: preparation and characterization of relaxivity.
PG  - 77-80
AB  - Gadolinium diethylenetriaminepentaacetic acid (DTPA) has not proved particularly 
      useful for hepatosplenic magnetic resonance imaging. However, by entrapping the 
      Gd-DTPA within lipid vesicles, one may exploit the ability of the 
      reticuloendothelial system to endocytose particulates, permitting passive 
      delivery of contrast agent to the liver and spleen while decreasing the rate of 
      clearance of Gd-DTPA from the vasculature. Liposomes of 70-400 nm diameter 
      containing Gd-DTPA were prepared by a freeze-thaw extrusion process. These 
      exhibited high trapping efficiencies and excellent stability during storage. For 
      all sizes of liposomes, the relaxivity of the entrapped Gd-DTPA was less than 
      that of free Gd-DTPA. Relaxivity varied linearly with the surface-area-to-volume 
      ratio of the liposomes; the smaller the liposomes, the greater the relaxivity. 
      Liposomes containing cholesterol had a lower relaxivity than liposomes without 
      cholesterol. The authors suggest this reflects the decrease in the water 
      permeability coefficient caused by the presence of cholesterol in the liposome 
      membrane.
FAU - Tilcock, C
AU  - Tilcock C
AD  - Department of Biochemistry, University of British Columbia, Vancouver, Canada.
FAU - Unger, E
AU  - Unger E
FAU - Cullis, P
AU  - Cullis P
FAU - MacDougall, P
AU  - MacDougall P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Liposomes)
RN  - 0 (Organometallic Compounds)
RN  - 7A314HQM0I (Pentetic Acid)
RN  - AU0V1LM3JT (Gadolinium)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - *Contrast Media
MH  - *Gadolinium
MH  - Gadolinium DTPA
MH  - Humans
MH  - *Liposomes
MH  - Liver/anatomy & histology
MH  - *Magnetic Resonance Imaging
MH  - Models, Structural
MH  - *Organometallic Compounds
MH  - *Pentetic Acid
MH  - Spleen/anatomy & histology
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
AID - 10.1148/radiology.171.1.2928549 [doi]
PST - ppublish
SO  - Radiology. 1989 Apr;171(1):77-80. doi: 10.1148/radiology.171.1.2928549.