PMID- 2934737
OWN - NLM
STAT- MEDLINE
DCOM- 19860207
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 82
IP  - 24
DP  - 1985 Dec
TI  - Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are 
      antigenically related.
PG  - 8729-32
AB  - A synthetic peptide (Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr), homologous to the 
      amino terminus of a protein purified from cerebrovascular amyloid (beta protein), 
      induced antibodies in BALB/c mice that were used immunohistochemically to stain 
      not only amyloid-laden cerebral vessels but neuritic plaques as well. These 
      findings suggest that the amyloid in neuritic plaques shares antigenic 
      determinants with beta protein of cerebral vessels. Since the amino acid 
      compositions of plaque amyloid and cerebrovascular amyloid are similar, it is 
      likely that plaque amyloid also consists of beta protein. This possibility 
      suggests a model for the pathogenesis of Alzheimer disease involving beta 
      protein.
FAU - Wong, C W
AU  - Wong CW
FAU - Quaranta, V
AU  - Quaranta V
FAU - Glenner, G G
AU  - Glenner GG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Amyloid)
RN  - 0 (Amyloid beta-Peptides)
SB  - IM
MH  - Alzheimer Disease/*pathology
MH  - Amino Acid Sequence
MH  - Amyloid/*metabolism
MH  - Amyloid beta-Peptides
MH  - Brain/pathology
MH  - Down Syndrome/*pathology
MH  - Humans
MH  - Immunologic Techniques
PMC - PMC391510
EDAT- 1985/12/01 00:00
MHDA- 1985/12/01 00:01
PMCR- 1986/06/01
CRDT- 1985/12/01 00:00
PHST- 1985/12/01 00:00 [pubmed]
PHST- 1985/12/01 00:01 [medline]
PHST- 1985/12/01 00:00 [entrez]
PHST- 1986/06/01 00:00 [pmc-release]
AID - 10.1073/pnas.82.24.8729 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1985 Dec;82(24):8729-32. doi: 10.1073/pnas.82.24.8729.