PMID- 31027351
OWN - NLM
STAT- MEDLINE
DCOM- 20190819
LR  - 20200225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 9
DP  - 2019 Apr 26
TI  - Self-Assembled Supramolecular Ribbon-Like Structures Complexed to Single Walled 
      Carbon Nanotubes as Possible Anticancer Drug Delivery Systems.
LID - 10.3390/ijms20092064 [doi]
LID - 2064
AB  - Designing an effective targeted anticancer drug delivery method is still a big 
      challenge, since chemotherapeutics often cause a variety of undesirable side 
      effects affecting normal tissues. This work presents the research on a novel 
      system consisting of single walled carbon nanotubes (SWNT), dispersed with Congo 
      Red (CR), a compound that forms self-assembled ribbon-like structures (SRLS) and 
      anticancer drug doxorubicin (DOX). SWNT provide a large surface for binding of 
      planar aromatic compounds, including drugs, while CR supramolecular ribbon-like 
      assemblies can be intercalated by drugs, like anthracycline rings containing DOX. 
      The mechanism of interactions in SWNT-CR-DOX triple system was proposed based on 
      electrophoretic, spectral, Dynamic Light Scattering and scanning electron 
      microscopy analyzes. The profile of drug release from the investigated system was 
      evaluated using dialysis and Differential Scanning Calorimetry. The results 
      indicate that ribbon-like supramolecular structures of CR bind to SWNT surface 
      forming SWNT-CR complexes which finally bind DOX. The high amount of 
      nanotube-bound CR greatly increases the capacity of the carrier for the drug. The 
      high capacity for drug binding and possible control of its release (through pH 
      changes) in the analyzed system may result in prolonged and localized drug 
      action. The proposed SWNT-CR-DOX triple system meets the basic criteria that 
      justifies its further research as a potential drug carrier.
FAU - Jagusiak, Anna
AU  - Jagusiak A
AD  - Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University 
      Medical College, Kopernika 7, 31-034 Krakow, Poland. anna.jagusiak@uj.edu.pl.
FAU - Chlopas, Katarzyna
AU  - Chlopas K
AD  - Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University 
      Medical College, Kopernika 7, 31-034 Krakow, Poland. katarzyna.chlopas@gmail.com.
FAU - Zemanek, Grzegorz
AU  - Zemanek G
AUID- ORCID: 0000-0003-4861-4397
AD  - Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University 
      Medical College, Kopernika 7, 31-034 Krakow, Poland. grzegorz.zemanek@uj.edu.pl.
FAU - Jemiola-Rzeminska, Malgorzata
AU  - Jemiola-Rzeminska M
AUID- ORCID: 0000-0001-7790-4831
AD  - Department of Plant Physiology and Biochemistry, Faculty of Biochemistry, 
      Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 
      Krakow, Poland. malgorzata.jemiola-rzeminska@uj.edu.pl.
AD  - Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 
      30-387 Krakow, Poland. malgorzata.jemiola-rzeminska@uj.edu.pl.
FAU - Piekarska, Barbara
AU  - Piekarska B
AD  - Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University 
      Medical College, Kopernika 7, 31-034 Krakow, Poland. barbara.piekarska@uj.edu.pl.
FAU - Stopa, Barbara
AU  - Stopa B
AD  - Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University 
      Medical College, Kopernika 7, 31-034 Krakow, Poland. mbstopa@cyf-kr.edu.pl.
FAU - Panczyk, Tomasz
AU  - Panczyk T
AD  - Institute of Catalysis and Surface Chemistry, Polish Academy of Science, 
      Niezapominajek 8, 30-239 Krakow, Poland. panczyk@vega.umcs.lublin.pl.
LA  - eng
GR  - 2016/21/D/NZ1/02763/National Science Centre, Poland/
PT  - Journal Article
DEP - 20190426
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Nanotubes, Carbon)
RN  - 3U05FHG59S (Congo Red)
RN  - 80168379AG (Doxorubicin)
MH  - Antibiotics, Antineoplastic/*chemistry
MH  - Antineoplastic Agents/*chemistry
MH  - Congo Red
MH  - Doxorubicin/chemistry
MH  - Drug Delivery Systems/*methods
MH  - Drug Liberation
MH  - Dynamic Light Scattering
MH  - Electrophoresis
MH  - Nanotubes, Carbon/*chemistry
PMC - PMC6539291
OTO - NOTNLM
OT  - Congo Red (CR)
OT  - doxorubicin (DOX)
OT  - self-assembled ribbon-like structures (SRLS)
OT  - single walled carbon nanotubes (SWNT)
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2019/04/28 06:00
MHDA- 2019/08/20 06:00
PMCR- 2019/05/01
CRDT- 2019/04/28 06:00
PHST- 2019/04/01 00:00 [received]
PHST- 2019/04/22 00:00 [revised]
PHST- 2019/04/24 00:00 [accepted]
PHST- 2019/04/28 06:00 [entrez]
PHST- 2019/04/28 06:00 [pubmed]
PHST- 2019/08/20 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - ijms20092064 [pii]
AID - ijms-20-02064 [pii]
AID - 10.3390/ijms20092064 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Apr 26;20(9):2064. doi: 10.3390/ijms20092064.