PMID- 31067458
OWN - NLM
STAT- MEDLINE
DCOM- 20200701
LR  - 20211204
IS  - 2211-1247 (Electronic)
VI  - 27
IP  - 6
DP  - 2019 May 7
TI  - Linking YAP to Muller Glia Quiescence Exit in the Degenerative Retina.
PG  - 1712-1725.e6
LID - S2211-1247(19)30510-8 [pii]
LID - 10.1016/j.celrep.2019.04.045 [doi]
AB  - Contrasting with fish or amphibian, retinal regeneration from Muller glia is 
      largely limited in mammals. In our quest toward the identification of molecular 
      cues that may boost their stemness potential, we investigated the involvement of 
      the Hippo pathway effector YAP (Yes-associated protein), which is upregulated in 
      Muller cells following retinal injury. Conditional Yap deletion in mouse Muller 
      cells prevents cell-cycle gene upregulation that normally accompanies reactive 
      gliosis upon photoreceptor cell death. We further show that, in Xenopus, a 
      species endowed with efficient regenerative capacity, YAP is required for their 
      injury-dependent proliferative response. In the mouse retina, where Muller cells 
      do not spontaneously proliferate, YAP overactivation is sufficient to induce 
      their reprogramming into highly proliferative cells. Overall, we unravel a 
      pivotal role for YAP in tuning Muller cell proliferative response to injury and 
      highlight a YAP-EGFR (epidermal growth factor receptor) axis by which Muller 
      cells exit their quiescence state, a critical step toward regeneration.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Hamon, Annaig
AU  - Hamon A
AD  - Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Univ Paris 
      Sud, Universite Paris-Saclay, Orsay 91405, France.
FAU - Garcia-Garcia, Diana
AU  - Garcia-Garcia D
AD  - Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Univ Paris 
      Sud, Universite Paris-Saclay, Orsay 91405, France.
FAU - Ail, Divya
AU  - Ail D
AD  - Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Univ Paris 
      Sud, Universite Paris-Saclay, Orsay 91405, France.
FAU - Bitard, Juliette
AU  - Bitard J
AD  - Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Univ Paris 
      Sud, Universite Paris-Saclay, Orsay 91405, France.
FAU - Chesneau, Albert
AU  - Chesneau A
AD  - Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Univ Paris 
      Sud, Universite Paris-Saclay, Orsay 91405, France.
FAU - Dalkara, Deniz
AU  - Dalkara D
AD  - Sorbonne Universite, UPMC Univ Paris 06, INSERM, CNRS, Institut de la Vision, 
      Paris, France.
FAU - Locker, Morgane
AU  - Locker M
AD  - Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Univ Paris 
      Sud, Universite Paris-Saclay, Orsay 91405, France.
FAU - Roger, Jerome E
AU  - Roger JE
AD  - Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Univ Paris 
      Sud, Universite Paris-Saclay, Orsay 91405, France. Electronic address: 
      jerome.roger@u-psud.fr.
FAU - Perron, Muriel
AU  - Perron M
AD  - Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Univ Paris 
      Sud, Universite Paris-Saclay, Orsay 91405, France. Electronic address: 
      muriel.perron@u-psud.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Xenopus Proteins)
RN  - 0 (YAP protein, Xenopus)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (Yap1 protein, mouse)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*metabolism
MH  - Animals
MH  - *Cell Cycle/genetics
MH  - Cell Cycle Proteins/*metabolism
MH  - Cell Proliferation
MH  - Ependymoglial Cells/metabolism/*pathology
MH  - Epidermal Growth Factor/metabolism
MH  - Humans
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neuroglia/metabolism/*pathology
MH  - Photoreceptor Cells, Vertebrate/metabolism/pathology
MH  - Retina/metabolism/pathology
MH  - Retinal Degeneration/genetics/*pathology
MH  - Signal Transduction
MH  - Trans-Activators/*metabolism
MH  - Transcription, Genetic
MH  - Up-Regulation/genetics
MH  - Xenopus Proteins/*metabolism
MH  - Xenopus laevis
MH  - YAP-Signaling Proteins
OTO - NOTNLM
OT  - EGFR pathway
OT  - Hippo/YAP pathway
OT  - Muller cells
OT  - reactive gliosis
OT  - retinal regeneration
EDAT- 2019/05/09 06:00
MHDA- 2020/07/02 06:00
CRDT- 2019/05/09 06:00
PHST- 2018/10/26 00:00 [received]
PHST- 2019/02/25 00:00 [revised]
PHST- 2019/04/09 00:00 [accepted]
PHST- 2019/05/09 06:00 [entrez]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2020/07/02 06:00 [medline]
AID - S2211-1247(19)30510-8 [pii]
AID - 10.1016/j.celrep.2019.04.045 [doi]
PST - ppublish
SO  - Cell Rep. 2019 May 7;27(6):1712-1725.e6. doi: 10.1016/j.celrep.2019.04.045.