PMID- 31270418
OWN - NLM
STAT- MEDLINE
DCOM- 20191223
LR  - 20211204
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 19
IP  - 8
DP  - 2019 Aug
TI  - YAP and TAZ: a signalling hub of the tumour microenvironment.
PG  - 454-464
LID - 10.1038/s41568-019-0168-y [doi]
AB  - YAP and TAZ are transcriptional activators pervasively induced in several human 
      solid tumours and their functions in cancer cells are the focus of intense 
      investigation. These studies established that YAP and TAZ are essential to 
      trigger numerous cell-autonomous responses, such as sustained proliferation, cell 
      plasticity, therapy resistance and metastasis. Yet tumours are complex entities, 
      wherein cancer cells are just one of the components of a composite "tumour 
      tissue". The other component, the tumour stroma, is composed of an extracellular 
      matrix with aberrant mechanical properties and other cell types, including 
      cancer-associated fibroblasts and immune cells. The stroma entertains multiple 
      and bidirectional interactions with tumour cells, establishing dependencies 
      essential to unleash tumorigenesis. The molecular players of such interplay 
      remain partially understood. Here, we review the emerging role of YAP and TAZ in 
      choreographing tumour-stromal interactions. YAP and TAZ act within tumour cells 
      to orchestrate responses in stromal cells. Vice versa, YAP and TAZ in stromal 
      cells trigger effects that positively feed back on the growth of tumour cells. 
      Recognizing YAP and TAZ as a hub of the network of signals exchanged within the 
      tumour microenvironment provides a fresh perspective on the molecular principles 
      of tumour self-organization, promising to unveil numerous new vulnerabilities.
FAU - Zanconato, Francesca
AU  - Zanconato F
AD  - Department of Molecular Medicine, University of Padova, Padua, Italy.
FAU - Cordenonsi, Michelangelo
AU  - Cordenonsi M
AD  - Department of Molecular Medicine, University of Padova, Padua, Italy.
FAU - Piccolo, Stefano
AU  - Piccolo S
AUID- ORCID: 0000-0002-1600-3092
AD  - Department of Molecular Medicine, University of Padova, Padua, Italy. 
      piccolo@bio.unipd.it.
AD  - IFOM, The FIRC Institute of Molecular Oncology, Padua, Italy. 
      piccolo@bio.unipd.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Transcriptional Coactivator with PDZ-Binding Motif Proteins)
RN  - 0 (WWTR1 protein, human)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YAP1 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*physiology
MH  - Animals
MH  - Carcinogenesis
MH  - Cell Adhesion
MH  - Cell Proliferation
MH  - Extracellular Matrix/metabolism
MH  - Humans
MH  - Mice
MH  - Neoplasm Metastasis
MH  - Neoplasms/*genetics/metabolism
MH  - Phenotype
MH  - Signal Transduction
MH  - Stromal Cells/metabolism
MH  - Trans-Activators
MH  - Transcription Factors/*physiology
MH  - Transcriptional Coactivator with PDZ-Binding Motif Proteins
MH  - *Tumor Microenvironment
MH  - YAP-Signaling Proteins
EDAT- 2019/07/05 06:00
MHDA- 2019/12/24 06:00
CRDT- 2019/07/05 06:00
PHST- 2019/07/05 06:00 [pubmed]
PHST- 2019/12/24 06:00 [medline]
PHST- 2019/07/05 06:00 [entrez]
AID - 10.1038/s41568-019-0168-y [pii]
AID - 10.1038/s41568-019-0168-y [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2019 Aug;19(8):454-464. doi: 10.1038/s41568-019-0168-y.