PMID- 3142689
OWN - NLM
STAT- MEDLINE
DCOM- 19890104
LR  - 20211203
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 55
IP  - 5
DP  - 1988 Dec 2
TI  - The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1.
PG  - 875-85
AB  - Binding of the human transcription factor Jun/AP-1 to a conserved 8 bp nucleotide 
      sequence (TRE) is responsible for increased transcription of different cellular 
      genes in response to tumor promoters, such as TPA, and serum factors. Enhanced 
      Jun/AP-1 activity in TPA-stimulated cells is regulated by two different 
      mechanisms: a posttranslational event acting on pre-existing Jun/AP-1 molecules, 
      and transcriptional activation of jun gene expression leading to an increase in 
      the total amount of Jun/AP-1. Induction of jun transcription in response to TPA 
      is mediated by binding of Jun/AP-1 to a high-affinity AP-1 binding site in the 
      jun promoter region. Site-specific mutagenesis of this binding site prevents TPA 
      induction and trans-activation by Jun/AP-1. These results clearly demonstrate 
      that jun transcription is directly stimulated by its own gene product. This 
      positive regulatory loop is likely to be responsible for prolonging the transient 
      signals generated by activation of protein kinase C.
FAU - Angel, P
AU  - Angel P
AD  - Department of Pharmacology, School of Medicine, University of California, San 
      Diego, La Jolla, 92093.
FAU - Hattori, K
AU  - Hattori K
FAU - Smeal, T
AU  - Smeal T
FAU - Karin, M
AU  - Karin M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Transcription Factors)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - DNA Mutational Analysis
MH  - DNA-Binding Proteins/*genetics
MH  - Gene Expression Regulation
MH  - Humans
MH  - Promoter Regions, Genetic
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins/physiology
MH  - Proto-Oncogene Proteins c-fos
MH  - Proto-Oncogene Proteins c-jun
MH  - *Proto-Oncogenes
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Transcription Factors/*genetics
EDAT- 1988/12/02 00:00
MHDA- 1988/12/02 00:01
CRDT- 1988/12/02 00:00
PHST- 1988/12/02 00:00 [pubmed]
PHST- 1988/12/02 00:01 [medline]
PHST- 1988/12/02 00:00 [entrez]
AID - 0092-8674(88)90143-2 [pii]
AID - 10.1016/0092-8674(88)90143-2 [doi]
PST - ppublish
SO  - Cell. 1988 Dec 2;55(5):875-85. doi: 10.1016/0092-8674(88)90143-2.