PMID- 31572799
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231014
IS  - 2380-6761 (Print)
IS  - 2380-6761 (Electronic)
IS  - 2380-6761 (Linking)
VI  - 4
IP  - 3
DP  - 2019 Sep
TI  - Nanoparticles in the clinic: An update.
PG  - e10143
LID - 10.1002/btm2.10143 [doi]
LID - e10143
AB  - Nanoparticle drug delivery systems have been used in the clinic since the early 
      1990's. Since that time, the field of nanomedicine has evolved alongside growing 
      technological needs to improve the delivery of various therapeutics. Over these 
      past decades, newer generations of nanoparticles have emerged that are capable of 
      performing additional delivery functions that can enable treatment via new 
      therapeutic modalities. In the current clinical landscape, many of these new 
      generation nanoparticles have reached clinical trials and have been approved for 
      various indications. In the first issue of Bioengineering & Translational 
      Medicine in 2016, we reviewed the history, current clinical landscape, and 
      clinical challenges of nanoparticle delivery systems. Here, we provide a 3 year 
      update on the current clinical landscape of nanoparticle drug delivery systems 
      and highlight newly approved nanomedicines, provide a status update on previous 
      clinical trials, and highlight new technologies that have recently entered the 
      clinic.
CI  - (c) 2019 The Authors. Bioengineering & Translational Medicine published by Wiley 
      Periodicals, Inc. on behalf of The American Institute of Chemical Engineers.
FAU - Anselmo, Aaron C
AU  - Anselmo AC
AUID- ORCID: 0000-0003-3290-7857
AD  - Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of 
      Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina.
FAU - Mitragotri, Samir
AU  - Mitragotri S
AUID- ORCID: 0000-0002-2459-8305
AD  - John A Paulson School of Engineering and Applied Sciences Harvard University, 
      Wyss Institute of Biologically Inspired Engineering Cambridge Massachusetts.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190905
PL  - United States
TA  - Bioeng Transl Med
JT  - Bioengineering & translational medicine
JID - 101689146
PMC - PMC6764803
OTO - NOTNLM
OT  - clinic
OT  - clinical translation
OT  - clinical trials
OT  - drug delivery
OT  - nanomedicine
OT  - nanoparticles
OT  - translational medicine
EDAT- 2019/10/02 06:00
MHDA- 2019/10/02 06:01
PMCR- 2019/09/05
CRDT- 2019/10/02 06:00
PHST- 2019/08/05 00:00 [received]
PHST- 2019/08/22 00:00 [revised]
PHST- 2019/08/23 00:00 [accepted]
PHST- 2019/10/02 06:00 [entrez]
PHST- 2019/10/02 06:00 [pubmed]
PHST- 2019/10/02 06:01 [medline]
PHST- 2019/09/05 00:00 [pmc-release]
AID - BTM210143 [pii]
AID - 10.1002/btm2.10143 [doi]
PST - epublish
SO  - Bioeng Transl Med. 2019 Sep 5;4(3):e10143. doi: 10.1002/btm2.10143. eCollection 
      2019 Sep.