PMID- 3201255
OWN - NLM
STAT- MEDLINE
DCOM- 19890126
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 242
IP  - 4886
DP  - 1988 Dec 23
TI  - Development of disease and virus recovery in transgenic mice containing HIV 
      proviral DNA.
PG  - 1665-70
AB  - Transgenic mice containing intact copies of the human immunodeficiency virus 
      (HIV) proviral DNA were constructed. Founder animals were not viremic for HIV and 
      remained healthy during a 9-month observation period. After being mated with 
      nontransgenic animals, one founder mouse (No. 13) gave rise to F1 progeny that 
      developed a disease syndrome characterized by marked epidermal hyperplasia, 
      lymphadenopathy, splenomegaly, pulmonary lymphoid infiltrates, growth 
      retardation, and death by day 25 of life. Infectious HIV, indistinguishable from 
      parental virus by immunoblot analysis, was recovered from the spleen, lymph 
      nodes, and skin of five of five affected animals.
FAU - Leonard, J M
AU  - Leonard JM
AD  - Laboratory of Molecular Microbiology, National Institute of Allergy and 
      Infectious Diseases, Bethesda, MD 20892.
FAU - Abramczuk, J W
AU  - Abramczuk JW
FAU - Pezen, D S
AU  - Pezen DS
FAU - Rutledge, R
AU  - Rutledge R
FAU - Belcher, J H
AU  - Belcher JH
FAU - Hakim, F
AU  - Hakim F
FAU - Shearer, G
AU  - Shearer G
FAU - Lamperth, L
AU  - Lamperth L
FAU - Travis, W
AU  - Travis W
FAU - Fredrickson, T
AU  - Fredrickson T
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (DNA Probes)
RN  - 0 (DNA, Viral)
RN  - 0 (HIV Antibodies)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/immunology/*microbiology/pathology
MH  - Animals
MH  - DNA Probes
MH  - *DNA, Viral/analysis
MH  - *Disease Models, Animal
MH  - Epidermis/pathology
MH  - HIV/*genetics/immunology/isolation & purification
MH  - HIV Antibodies/analysis
MH  - Lung/pathology
MH  - Lymph Nodes/microbiology/pathology
MH  - Mice
MH  - Mice, Transgenic
MH  - Nucleic Acid Hybridization
MH  - Skin/microbiology/pathology
MH  - Spleen/microbiology/pathology
EDAT- 1988/12/23 00:00
MHDA- 1988/12/23 00:01
CRDT- 1988/12/23 00:00
PHST- 1988/12/23 00:00 [pubmed]
PHST- 1988/12/23 00:01 [medline]
PHST- 1988/12/23 00:00 [entrez]
AID - 10.1126/science.3201255 [doi]
PST - ppublish
SO  - Science. 1988 Dec 23;242(4886):1665-70. doi: 10.1126/science.3201255.