PMID- 3276004
OWN - NLM
STAT- MEDLINE
DCOM- 19880217
LR  - 20220330
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 239
IP  - 4837
DP  - 1988 Jan 15
TI  - Perivascular microglial cells of the CNS are bone marrow-derived and present 
      antigen in vivo.
PG  - 290-2
AB  - A crucial question in the study of immunological reactions in the central nervous 
      system (CNS) concerns the identity of the parenchymal cells that function as the 
      antigen-presenting cells in that organ. Rat bone marrow chimeras and 
      encephalitogenic, major histocompatability--restricted T-helper lymphocytes were 
      used to show that a subset of endogenous CNS cells, commonly termed "perivascular 
      microglial cells," is bone marrow-derived. In addition, these perivascular cells 
      are fully competent to present antigen to lymphocytes in an appropriately 
      restricted manner. These findings are important for bone marrow transplantation 
      and for neuroimmunological diseases such as multiple sclerosis.
FAU - Hickey, W F
AU  - Hickey WF
AD  - Department of Pathology and Laboratory Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104-6079.
FAU - Kimura, H
AU  - Kimura H
LA  - eng
GR  - KO7-NS0087/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Histocompatibility Antigens)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/*immunology
MH  - Astrocytes/immunology
MH  - Bone Marrow/*immunology
MH  - Bone Marrow Transplantation
MH  - Central Nervous System/blood supply/*immunology/pathology
MH  - Chimera
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/pathology
MH  - Endothelium/immunology
MH  - Graft vs Host Disease/immunology
MH  - Histocompatibility Antigens/analysis/immunology
MH  - Immunohistochemistry
MH  - Multiple Sclerosis/immunology/pathology
MH  - Neuroglia/*immunology
MH  - Rats
MH  - Rats, Inbred Lew
MH  - T-Lymphocytes/immunology
EDAT- 1988/01/15 00:00
MHDA- 1988/01/15 00:01
CRDT- 1988/01/15 00:00
PHST- 1988/01/15 00:00 [pubmed]
PHST- 1988/01/15 00:01 [medline]
PHST- 1988/01/15 00:00 [entrez]
AID - 10.1126/science.3276004 [doi]
PST - ppublish
SO  - Science. 1988 Jan 15;239(4837):290-2. doi: 10.1126/science.3276004.