PMID- 32967005
OWN - NLM
STAT- MEDLINE
DCOM- 20201029
LR  - 20231111
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 586
IP  - 7830
DP  - 2020 Oct
TI  - Animal models for COVID-19.
PG  - 509-515
LID - 10.1038/s41586-020-2787-6 [doi]
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological 
      agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection 
      caused by the introduction of a novel coronavirus into humans late in 2019 (first 
      detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has 
      spread to 215 countries, has infected more than 30 million people and has caused 
      more than 950,000 deaths. As humans do not have pre-existing immunity to 
      SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to 
      mitigate the current pandemic and to prevent the re-emergence of COVID-19. In 
      February 2020, the World Health Organization (WHO) assembled an international 
      panel to develop animal models for COVID-19 to accelerate the testing of vaccines 
      and therapeutic agents. Here we summarize the findings to date and provides 
      relevant information for preclinical testing of vaccine candidates and 
      therapeutic agents for COVID-19.
FAU - Munoz-Fontela, Cesar
AU  - Munoz-Fontela C
AD  - Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
AD  - German Center for Infection Research (DZIF), Partner site 
      Hamburg-Lubeck-Borstel-Riems, Hamburg, Germany.
FAU - Dowling, William E
AU  - Dowling WE
AD  - Centre for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA.
FAU - Funnell, Simon G P
AU  - Funnell SGP
AUID- ORCID: 0000-0002-4254-2751
AD  - National Infection Service, Public Health England, Salisbury, UK.
FAU - Gsell, Pierre-S
AU  - Gsell PS
AD  - World Health Organization, Geneva, Switzerland.
FAU - Riveros-Balta, A Ximena
AU  - Riveros-Balta AX
AD  - World Health Organization, Geneva, Switzerland.
FAU - Albrecht, Randy A
AU  - Albrecht RA
AUID- ORCID: 0000-0003-4008-503X
AD  - Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn 
      School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Andersen, Hanne
AU  - Andersen H
AUID- ORCID: 0000-0003-1103-9608
AD  - Bioqual Inc, Rockville, MD, USA.
FAU - Baric, Ralph S
AU  - Baric RS
AUID- ORCID: 0000-0001-6827-8701
AD  - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC, USA.
FAU - Carroll, Miles W
AU  - Carroll MW
AD  - National Infection Service, Public Health England, Salisbury, UK.
FAU - Cavaleri, Marco
AU  - Cavaleri M
AD  - European Medicines Agency, Amsterdam, The Netherlands.
FAU - Qin, Chuan
AU  - Qin C
AUID- ORCID: 0000-0002-6261-1232
AD  - Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and 
      Peking Union Medical College, Peking, China.
FAU - Crozier, Ian
AU  - Crozier I
AD  - Clinical Monitoring Research Program Directorate, Frederick National Laboratory 
      for Cancer Research, Frederick, MD, USA.
FAU - Dallmeier, Kai
AU  - Dallmeier K
AD  - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega 
      Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
FAU - de Waal, Leon
AU  - de Waal L
AD  - Viroclinics Xplore, Schaijk, The Netherlands.
FAU - de Wit, Emmie
AU  - de Wit E
AUID- ORCID: 0000-0002-9763-7758
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Delang, Leen
AU  - Delang L
AUID- ORCID: 0000-0002-8874-675X
AD  - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega 
      Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
FAU - Dohm, Erik
AU  - Dohm E
AD  - Animal Resources Program, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Duprex, W Paul
AU  - Duprex WP
AUID- ORCID: 0000-0003-1716-6376
AD  - Department of Microbiology and Molecular Genetics, Center for Vaccine Research, 
      University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Falzarano, Darryl
AU  - Falzarano D
AD  - VIDO-Intervac, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
FAU - Finch, Courtney L
AU  - Finch CL
AD  - Integrated Research Facility at Fort Detrick, National Institute of Allergy and 
      Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
FAU - Frieman, Matthew B
AU  - Frieman MB
AUID- ORCID: 0000-0003-0107-0775
AD  - Department of Microbiology and Immunology, University of Maryland School of 
      Medicine, Baltimore, MD, USA.
FAU - Graham, Barney S
AU  - Graham BS
AD  - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Bethesda, MD, USA.
FAU - Gralinski, Lisa E
AU  - Gralinski LE
AD  - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC, USA.
FAU - Guilfoyle, Kate
AU  - Guilfoyle K
AD  - Viroclinics Xplore, Schaijk, The Netherlands.
FAU - Haagmans, Bart L
AU  - Haagmans BL
AUID- ORCID: 0000-0001-6221-2015
AD  - Department of Viroscience, Erasmus University Medical Center, Rotterdam, The 
      Netherlands.
FAU - Hamilton, Geraldine A
AU  - Hamilton GA
AD  - Emulate Inc, Boston, MA, USA.
FAU - Hartman, Amy L
AU  - Hartman AL
AUID- ORCID: 0000-0002-0857-2973
AD  - Department of Microbiology and Molecular Genetics, Center for Vaccine Research, 
      University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Herfst, Sander
AU  - Herfst S
AUID- ORCID: 0000-0001-9866-8903
AD  - Department of Viroscience, Erasmus University Medical Center, Rotterdam, The 
      Netherlands.
FAU - Kaptein, Suzanne J F
AU  - Kaptein SJF
AUID- ORCID: 0000-0002-7935-0219
AD  - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega 
      Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
FAU - Klimstra, William B
AU  - Klimstra WB
AD  - Department of Immunology, Center for Vaccine Research, University of Pittsburgh, 
      Pittsburgh, PA, USA.
FAU - Knezevic, Ivana
AU  - Knezevic I
AD  - World Health Organization, Geneva, Switzerland.
FAU - Krause, Philip R
AU  - Krause PR
AUID- ORCID: 0000-0002-1045-7536
AD  - Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, USA.
FAU - Kuhn, Jens H
AU  - Kuhn JH
AUID- ORCID: 0000-0002-7800-6045
AD  - Integrated Research Facility at Fort Detrick, National Institute of Allergy and 
      Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
FAU - Le Grand, Roger
AU  - Le Grand R
AUID- ORCID: 0000-0002-4928-4484
AD  - Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases 
      (IMVA-HB/IDMIT), Inserm, CEA, Universite Paris-Saclay, Paris, France.
FAU - Lewis, Mark G
AU  - Lewis MG
AD  - Bioqual Inc, Rockville, MD, USA.
FAU - Liu, Wen-Chun
AU  - Liu WC
AD  - Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn 
      School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Maisonnasse, Pauline
AU  - Maisonnasse P
AUID- ORCID: 0000-0002-0555-207X
AD  - Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases 
      (IMVA-HB/IDMIT), Inserm, CEA, Universite Paris-Saclay, Paris, France.
FAU - McElroy, Anita K
AU  - McElroy AK
AD  - Division of Pediatric Infectious Diseases, Center for Vaccine Research, 
      University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
FAU - Munster, Vincent
AU  - Munster V
AUID- ORCID: 0000-0002-2288-3196
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Oreshkova, Nadia
AU  - Oreshkova N
AD  - Wageningen Bioveterinary Research (WBVR), Wageningen University and Research, 
      Lelystad, The Netherlands.
FAU - Rasmussen, Angela L
AU  - Rasmussen AL
AD  - Center for Infection and Immunity, Columbia Mailman |School of Public Health, New 
      York, NY, USA.
FAU - Rocha-Pereira, Joana
AU  - Rocha-Pereira J
AD  - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega 
      Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
FAU - Rockx, Barry
AU  - Rockx B
AUID- ORCID: 0000-0003-2463-027X
AD  - Department of Viroscience, Erasmus University Medical Center, Rotterdam, The 
      Netherlands.
FAU - Rodriguez, Estefania
AU  - Rodriguez E
AD  - Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
AD  - German Center for Infection Research (DZIF), Partner site 
      Hamburg-Lubeck-Borstel-Riems, Hamburg, Germany.
FAU - Rogers, Thomas F
AU  - Rogers TF
AD  - Division of Infectious Diseases, University of California San Diego, San Diego, 
      CA, USA.
FAU - Salguero, Francisco J
AU  - Salguero FJ
AD  - National Infection Service, Public Health England, Salisbury, UK.
FAU - Schotsaert, Michael
AU  - Schotsaert M
AUID- ORCID: 0000-0003-3156-3132
AD  - Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn 
      School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Stittelaar, Koert J
AU  - Stittelaar KJ
AD  - Viroclinics Xplore, Schaijk, The Netherlands.
FAU - Thibaut, Hendrik Jan
AU  - Thibaut HJ
AUID- ORCID: 0000-0001-5785-8276
AD  - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega 
      Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
FAU - Tseng, Chien-Te
AU  - Tseng CT
AD  - Department of Microbiology and Immunology, University of Texas Medical Branch, 
      Galveston, TX, USA.
FAU - Vergara-Alert, Julia
AU  - Vergara-Alert J
AD  - Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus Universitat 
      Autonoma de Barcelona, Bellaterra, Spain.
FAU - Beer, Martin
AU  - Beer M
AUID- ORCID: 0000-0002-0598-5254
AD  - Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel 
      Riems, Germany.
FAU - Brasel, Trevor
AU  - Brasel T
AD  - Department of Microbiology and Immunology, University of Texas Medical Branch, 
      Galveston, TX, USA.
FAU - Chan, Jasper F W
AU  - Chan JFW
AD  - Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of 
      Medicine, The University of Hong Kong, Hong Kong, China.
FAU - Garcia-Sastre, Adolfo
AU  - Garcia-Sastre A
AUID- ORCID: 0000-0002-6551-1827
AD  - Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn 
      School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Neyts, Johan
AU  - Neyts J
AD  - KU Leuven Department of Microbiology, Immunology and Transplantation, Rega 
      Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
FAU - Perlman, Stanley
AU  - Perlman S
AUID- ORCID: 0000-0003-4213-2354
AD  - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, 
      USA.
FAU - Reed, Douglas S
AU  - Reed DS
AD  - Department of Immunology, Center for Vaccine Research, University of Pittsburgh, 
      Pittsburgh, PA, USA.
FAU - Richt, Juergen A
AU  - Richt JA
AD  - College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
FAU - Roy, Chad J
AU  - Roy CJ
AUID- ORCID: 0000-0002-1710-6974
AD  - Tulane National Primate Research Center, Covington, LA, USA.
FAU - Segales, Joaquim
AU  - Segales J
AUID- ORCID: 0000-0002-1539-7261
AD  - Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus Universitat 
      Autonoma de Barcelona, Bellaterra, Spain.
AD  - Departament de Sanitat i Anatomia Animals, Facultat de Veterinaria, UAB, 
      Bellaterra, Spain.
FAU - Vasan, Seshadri S
AU  - Vasan SS
AUID- ORCID: 0000-0002-7326-3210
AD  - Australian Centre for Disease Preparedness, CSIRO, Geelong, Victoria, Australia.
AD  - Department of Health Sciences, University of York, York, UK.
FAU - Henao-Restrepo, Ana Maria
AU  - Henao-Restrepo AM
AD  - World Health Organization, Geneva, Switzerland. henaorestrepoa@who.int.
FAU - Barouch, Dan H
AU  - Barouch DH
AUID- ORCID: 0000-0001-5127-4659
AD  - Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, 
      Harvard Medical School, Boston, MA, USA. dbarouch@bidmc.harvard.edu.
LA  - eng
GR  - R01 AI157155/AI/NIAID NIH HHS/United States
GR  - P51 OD011104/OD/NIH HHS/United States
GR  - R01 AI148166/AI/NIAID NIH HHS/United States
GR  - R01 AI129269/AI/NIAID NIH HHS/United States
GR  - P01 AI060699/AI/NIAID NIH HHS/United States
GR  - 001/WHO_/World Health Organization/International
PT  - Journal Article
PT  - Review
DEP - 20200923
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (Viral Vaccines)
SB  - IM
CIN - Respirology. 2021 Mar;26(3):222-224. doi: 10.1111/resp.13997. PMID: 33350019
MH  - Animals
MH  - Betacoronavirus/drug effects/immunology
MH  - COVID-19
MH  - COVID-19 Vaccines
MH  - Coronavirus Infections/*drug therapy/immunology/*prevention & control
MH  - *Disease Models, Animal
MH  - Ferrets/virology
MH  - Humans
MH  - Mesocricetus/virology
MH  - Mice
MH  - Pandemics/*prevention & control
MH  - Pneumonia, Viral/*drug therapy/immunology/*prevention & control
MH  - Primates/virology
MH  - SARS-CoV-2
MH  - Viral Vaccines/immunology
PMC - PMC8136862
MID - NIHMS1700241
EDAT- 2020/09/24 06:00
MHDA- 2020/10/30 06:00
PMCR- 2021/05/20
CRDT- 2020/09/23 20:08
PHST- 2020/06/22 00:00 [received]
PHST- 2020/09/15 00:00 [accepted]
PHST- 2020/09/24 06:00 [pubmed]
PHST- 2020/10/30 06:00 [medline]
PHST- 2020/09/23 20:08 [entrez]
PHST- 2021/05/20 00:00 [pmc-release]
AID - 10.1038/s41586-020-2787-6 [pii]
AID - 10.1038/s41586-020-2787-6 [doi]
PST - ppublish
SO  - Nature. 2020 Oct;586(7830):509-515. doi: 10.1038/s41586-020-2787-6. Epub 2020 Sep 
      23.