PMID- 3327633
OWN - NLM
STAT- MEDLINE
DCOM- 19880502
LR  - 20200304
IS  - 0167-7659 (Print)
IS  - 0167-7659 (Linking)
VI  - 6
IP  - 4
DP  - 1987
TI  - Transport of molecules across tumor vasculature.
PG  - 559-93
AB  - The vascular-extravascular exchange of fluid and solute molecules in a tissue is 
      determined by three transport parameters (vascular permeability, P, hydraulic 
      conductivity, Lp, and reflection coefficient, sigma); the surface area for 
      exchange, A; and the transluminal concentration and pressure gradients. The 
      transport parameters and the exchange area for a given molecule are governed by 
      the structure of the vessel wall. In general, tumor vessels have wide 
      interendothelial junctions; large number of fenestrae and transendothelial 
      channels formed by vesicles; and discontinuous or absent basement membrane. While 
      these factors favor movement of molecules across tumor vessels, high interstitial 
      pressure and low microvascular pressure may retard extravasation of molecules and 
      cells, especially in large tumors. These characteristics of the transvascular 
      transport have significant implications in tumor growth, metastasis, detection 
      and treatment.
FAU - Jain, R K
AU  - Jain RK
AD  - Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 
      15213-3890.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - Cancer Metastasis Rev
JT  - Cancer metastasis reviews
JID - 8605731
SB  - IM
MH  - Animals
MH  - Biological Transport
MH  - Blood Vessels/metabolism
MH  - Capillaries/anatomy & histology/metabolism
MH  - Capillary Permeability/drug effects/radiation effects
MH  - Humans
MH  - Hyperthermia, Induced
MH  - Models, Biological
MH  - Neoplasms/*blood supply/therapy
MH  - Osmotic Pressure
RF  - 196
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1007/BF00047468 [doi]
PST - ppublish
SO  - Cancer Metastasis Rev. 1987;6(4):559-93. doi: 10.1007/BF00047468.