PMID- 3383245
OWN - NLM
STAT- MEDLINE
DCOM- 19880810
LR  - 20191210
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 54
IP  - 1
DP  - 1988 Jul 1
TI  - The bicoid protein determines position in the Drosophila embryo in a 
      concentration-dependent manner.
PG  - 95-104
AB  - The bicoid (bcd) protein in a Drosophila embryo is derived from an anteriorly 
      localized mRNA and comes to be distributed in an exponential concentration 
      gradient along the anteroposterior axis. To determine whether the levels of bcd 
      protein are directly related to certain cell fates, we manipulated the density 
      and distribution of bcd mRNA by genetic means, measured the resultant alterations 
      in height and shape of the bcd protein gradient, and correlated the gradient with 
      the fate map of the respective embryos. Increases or decreases in bcd protein 
      levels in a given region of the embryo cause a corresponding posterior or 
      anterior shift of anterior anlagen in the embryo. The bcd protein thus has the 
      properties of a morphogen that autonomously determines positions in the anterior 
      half of the embryo.
FAU - Driever, W
AU  - Driever W
AD  - Max-Planck-Institut fur Entwicklungsbiologie Abteilung III Genetik, Tubingen, 
      Federal Republic of Germany.
FAU - Nusslein-Volhard, C
AU  - Nusslein-Volhard C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Drosophila Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Insect Hormones)
RN  - 0 (RNA, Messenger)
RN  - 0 (Trans-Activators)
RN  - 0 (bcd protein, Drosophila)
SB  - IM
CIN - Cell. 2004 Jan 23;116(2):143-52. PMID: 14744427
CIN - Cell. 2004 Jan 23;116(2 Suppl):S1-5, 2 p following S9. PMID: 15055573
CIN - Cell. 2004 Jan 23;116(2 Suppl):S7-9, 2 p following S9. PMID: 15055574
MH  - Animals
MH  - Drosophila/*embryology/genetics
MH  - Drosophila Proteins
MH  - Female
MH  - Genotype
MH  - *Homeodomain Proteins
MH  - Immunohistochemistry
MH  - Insect Hormones/*analysis/genetics
MH  - Mutation
MH  - Phenotype
MH  - RNA, Messenger/analysis
MH  - *Trans-Activators
EDAT- 1988/07/01 00:00
MHDA- 1988/07/01 00:01
CRDT- 1988/07/01 00:00
PHST- 1988/07/01 00:00 [pubmed]
PHST- 1988/07/01 00:01 [medline]
PHST- 1988/07/01 00:00 [entrez]
AID - 0092-8674(88)90183-3 [pii]
AID - 10.1016/0092-8674(88)90183-3 [doi]
PST - ppublish
SO  - Cell. 1988 Jul 1;54(1):95-104. doi: 10.1016/0092-8674(88)90183-3.