PMID- 3466178
OWN - NLM
STAT- MEDLINE
DCOM- 19870114
LR  - 20210103
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 83
IP  - 23
DP  - 1986 Dec
TI  - Inhibition of tumor growth by a monoclonal antibody reactive with an 
      oncogene-encoded tumor antigen.
PG  - 9129-33
AB  - The neu oncogene encodes a 185-kDa transmembrane glycoprotein tumor antigen, 
      termed p185. We have recently described a monoclonal antibody reactive with a 
      cell surface domain of the p185 molecule. In vivo treatment with this anti-p185 
      monoclonal antibody was able to significantly inhibit the tumorigenic growth of 
      neu-transformed NIH 3T3 cells implanted into nude mice. Such treatment had no 
      effect on the tumorigenic growth of Ha-ras-transformed NIH 3T3 cells. 
      Furthermore, anti-p185 antibody treatment was able to inhibit the growth of the 
      rat neuroblastoma cells from which the neu oncogene was initially isolated. These 
      results demonstrate that a monoclonal antibody reactive with the extracellular 
      domain of an oncogene-encoded protein can exert a significant antitumor effect; 
      such antibodies may prove useful in the therapy of certain malignancies.
FAU - Drebin, J A
AU  - Drebin JA
FAU - Link, V C
AU  - Link VC
FAU - Weinberg, R A
AU  - Weinberg RA
FAU - Greene, M I
AU  - Greene MI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Neoplasm)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antigens, Surface)
RN  - 0 (Oncogene Proteins, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*immunology/therapeutic use
MH  - Antibodies, Neoplasm/immunology
MH  - Antibody Specificity
MH  - Antigens, Neoplasm/*immunology
MH  - Antigens, Surface/immunology
MH  - Mice
MH  - Mice, Nude
MH  - Neoplasms, Experimental/*prevention & control
MH  - Neuroblastoma/immunology
MH  - Oncogene Proteins, Viral/*immunology
MH  - Rats
PMC - PMC387088
EDAT- 1986/12/01 00:00
MHDA- 1986/12/01 00:01
PMCR- 1987/06/01
CRDT- 1986/12/01 00:00
PHST- 1986/12/01 00:00 [pubmed]
PHST- 1986/12/01 00:01 [medline]
PHST- 1986/12/01 00:00 [entrez]
PHST- 1987/06/01 00:00 [pmc-release]
AID - 10.1073/pnas.83.23.9129 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1986 Dec;83(23):9129-33. doi: 10.1073/pnas.83.23.9129.