PMID- 3487332
OWN - NLM
STAT- MEDLINE
DCOM- 19860729
LR  - 20191029
IS  - 0737-6006 (Print)
IS  - 0737-6006 (Linking)
VI  - 2
IP  - 2
DP  - 1986 Spring
TI  - Long-term follow-up of serum-interferon and its acid-stability in a group of 
      homosexual men.
PG  - 99-108
AB  - For a period of over two years 99 volunteer healthy homosexual men were examined 
      periodically for the presence of interferon (IFN) in their serum. Thirty-nine 
      subjects had either undetectable IFN levels in serum or IFN was detected only 
      once in three to five samples tested. In another 45 subjects low IFN levels were 
      detected throughout the study period. None of these subjects had or developed any 
      disease symptoms. In the remaining 15 subjects high serum IFN levels were 
      detected at their enrollment or during the study period. All these subjects 
      started to manifest clinical symptoms compatible with AIDS. In six subjects the 
      mean time elapsed between the first detection of serum IFN and disease symptoms 
      was 6.5 months. In all subjects but one, the IFN was of type alpha. The 
      acid-stability of serum IFN alpha decreased with time, and when its decrease was 
      abrupt it was associated with a more rapid evolution of AIDS. Sera containing 
      acid-labile IFN alpha can induce IFN alpha synthesis in normal lymphocyte 
      cultures (LC), but do not influence IFN gamma synthesis in LC stimulated with 
      phytohemagglutinin. LC stimulated with viral antigens in the presence of serum 
      with acid-labile IFN alpha synthesized IFN with an increased sensitivity for acid 
      treatment. The results confirm the prognostic value of serum IFN alpha in the 
      development of AIDS, and suggest that the transition to acid-lability may be a 
      gradual process.
FAU - Buimovici-Klein, E
AU  - Buimovici-Klein E
FAU - Lange, M
AU  - Lange M
FAU - Klein, R J
AU  - Klein RJ
FAU - Grieco, M H
AU  - Grieco MH
FAU - Cooper, L Z
AU  - Cooper LZ
LA  - eng
GR  - AI-121175/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - AIDS Res
JT  - AIDS research
JID - 8310361
RN  - 0 (Interferon Type I)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/blood
MH  - Cells, Cultured
MH  - Follow-Up Studies
MH  - *Homosexuality
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Interferon Type I/biosynthesis/*blood
MH  - Lymphocytes/metabolism
MH  - Male
MH  - Pneumonia, Pneumocystis/blood
MH  - Sarcoma, Kaposi/blood
MH  - Time Factors
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1089/aid.1.1986.2.99 [doi]
PST - ppublish
SO  - AIDS Res. 1986 Spring;2(2):99-108. doi: 10.1089/aid.1.1986.2.99.