PMID- 3494522
OWN - NLM
STAT- MEDLINE
DCOM- 19870529
LR  - 20201215
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 49
IP  - 2
DP  - 1987 Apr 24
TI  - T cell tolerance by clonal elimination in the thymus.
PG  - 273-80
AB  - The monoclonal antibody KJ23a reacts with T cell receptors utilizing the V beta 
      segment V beta 17a. T cells bearing V beta 17a+ receptors react with very high 
      frequency with the MHC class II protein, IE. In this paper we show that T cells 
      expressing V beta 17a are selectively eliminated from the peripheral T cell and 
      mature thymocyte pool of mice expressing IE, but are present in expected numbers 
      in the immature thymocyte population of such animals. These results show that in 
      normal animals tolerance to self-MHC is due to clonal elimination rather than 
      suppression. In addition, they indicate that tolerance induction may occur in the 
      thymus at the time immature thymocytes are selected to move into the mature 
      thymocyte pool.
FAU - Kappler, J W
AU  - Kappler JW
FAU - Roehm, N
AU  - Roehm N
FAU - Marrack, P
AU  - Marrack P
LA  - eng
GR  - AI-17134/AI/NIAID NIH HHS/United States
GR  - AI-18785/AI/NIAID NIH HHS/United States
GR  - P0I AI-22295/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Histocompatibility Antigens Class II/genetics
MH  - *Immune Tolerance
MH  - *Major Histocompatibility Complex
MH  - Mice
MH  - Mice, Inbred Strains/immunology
MH  - Receptors, Antigen, T-Cell/immunology
MH  - T-Lymphocytes/cytology/*immunology
MH  - Thymus Gland/*immunology
EDAT- 1987/04/24 00:00
MHDA- 1987/04/24 00:01
CRDT- 1987/04/24 00:00
PHST- 1987/04/24 00:00 [pubmed]
PHST- 1987/04/24 00:01 [medline]
PHST- 1987/04/24 00:00 [entrez]
AID - 0092-8674(87)90568-X [pii]
AID - 10.1016/0092-8674(87)90568-x [doi]
PST - ppublish
SO  - Cell. 1987 Apr 24;49(2):273-80. doi: 10.1016/0092-8674(87)90568-x.