PMID- 3512079
OWN - NLM
STAT- MEDLINE
DCOM- 19860423
LR  - 20201226
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 46
IP  - 4 Pt 2
DP  - 1986 Apr
TI  - Interleukin-2 or autologous lymphokine-activated killer cell treatment of 
      malignant glioma: phase I trial.
PG  - 2101-4
AB  - In a Phase I study, recombinant interleukin-2 (IL-2) or autochthohous 
      lymphokine-activated killer (LAK) cells were used to treat nine patients with 
      malignant glioma. One patient received the combination of IL-2 and LAK cells. LAK 
      cells were generated by culturing IL-2 with peripheral blood lymphocytes obtained 
      from brain tumor patients. Escalating doses of LAK cells (10(8)-10(10) or 
      recombinant IL-2 (10(4)-10(6) units) were administered by direct injection into 
      the brain tissue surrounding the cavity left following operative tumor removal. 
      There have been no signs of systemic or neurotoxicity following treatment. The 
      tumor selective killing of the LAK cells used for these treatments was 
      demonstrated by their ability to lyse glioma cells but not normal cells in vitro 
      using a chromium release microcytotoxicity assay.
FAU - Jacobs, S K
AU  - Jacobs SK
FAU - Wilson, D J
AU  - Wilson DJ
FAU - Kornblith, P L
AU  - Kornblith PL
FAU - Grimm, E A
AU  - Grimm EA
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Interleukin-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/*therapy
MH  - Clinical Trials as Topic
MH  - Cytotoxicity, Immunologic
MH  - Female
MH  - Glioma/*therapy
MH  - Humans
MH  - Immunotherapy/*methods
MH  - Interleukin-2/administration & dosage/*immunology
MH  - Killer Cells, Natural/*immunology/transplantation
MH  - Lymphocytes/immunology
MH  - Male
MH  - Middle Aged
EDAT- 1986/04/01 00:00
MHDA- 1986/04/01 00:01
CRDT- 1986/04/01 00:00
PHST- 1986/04/01 00:00 [pubmed]
PHST- 1986/04/01 00:01 [medline]
PHST- 1986/04/01 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1986 Apr;46(4 Pt 2):2101-4.