PMID- 3616618
OWN - NLM
STAT- MEDLINE
DCOM- 19870923
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 237
IP  - 4817
DP  - 1987 Aug 21
TI  - A parathyroid hormone-related protein implicated in malignant hypercalcemia: 
      cloning and expression.
PG  - 893-6
AB  - Humoral hypercalcemia of malignancy is a common complication of lung and certain 
      other cancers. The hypercalcemia results from the actions of tumor factors on 
      bone and kidney. We report here the isolation of full-length complementary DNA 
      clones of a putative hypercalcemia factor, and the expression from the cloned DNA 
      of the active protein in mammalian cells. The clones encode a prepro peptide of 
      36 amino acids and a mature protein of 141 amino acids that has significant 
      homology with parathyroid hormone in the amino-terminal region. This previously 
      unrecognized hormone may be important in normal as well as abnormal calcium 
      metabolism.
FAU - Suva, L J
AU  - Suva LJ
FAU - Winslow, G A
AU  - Winslow GA
FAU - Wettenhall, R E
AU  - Wettenhall RE
FAU - Hammonds, R G
AU  - Hammonds RG
FAU - Moseley, J M
AU  - Moseley JM
FAU - Diefenbach-Jagger, H
AU  - Diefenbach-Jagger H
FAU - Rodda, C P
AU  - Rodda CP
FAU - Kemp, B E
AU  - Kemp BE
FAU - Rodriguez, H
AU  - Rodriguez H
FAU - Chen, E Y
AU  - Chen EY
AU  - et al.
LA  - eng
SI  - GENBANK/M17183
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Neoplasm Proteins)
RN  - 0 (PTHLH protein, human)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Parathyroid Hormone-Related Protein)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA/genetics
MH  - Gene Expression Regulation
MH  - Humans
MH  - Hypercalcemia/*genetics
MH  - Lung Neoplasms/complications/*genetics
MH  - Neoplasm Proteins/*genetics
MH  - Parathyroid Hormone/genetics
MH  - Parathyroid Hormone-Related Protein
EDAT- 1987/08/21 00:00
MHDA- 1987/08/21 00:01
CRDT- 1987/08/21 00:00
PHST- 1987/08/21 00:00 [pubmed]
PHST- 1987/08/21 00:01 [medline]
PHST- 1987/08/21 00:00 [entrez]
AID - 10.1126/science.3616618 [doi]
PST - ppublish
SO  - Science. 1987 Aug 21;237(4817):893-6. doi: 10.1126/science.3616618.