PMID- 3622926 OWN - NLM STAT- MEDLINE DCOM- 19870929 LR - 20190721 IS - 0012-1606 (Print) IS - 0012-1606 (Linking) VI - 123 IP - 1 DP - 1987 Sep TI - Changing spatial patterns of DNA replication in the developing wing of Drosophila. PG - 145-53 AB - Using an antibody against bromodeoxyuridine we have analyzed the distribution of S-phase nuclei in the wing disc of Drosophila as the larval disc transforms into the adult wing during metamorphosis. On the basis of the timing of replication three cell populations can be distinguished: the cells of the presumptive wing margin, the precursor cells of the longitudinal veins, and those of the intervein regions. In each of these populations the cell cycle is first arrested and later resumes at a specific time, so that at each developmental time point a characteristic spatial pattern of S-phase nuclei is seen. An interpretation of these changing patterns in terms of vein formation, compartments, and neural development is offered. FAU - Schubiger, M AU - Schubiger M FAU - Palka, J AU - Palka J LA - eng GR - NS-07778/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Dev Biol JT - Developmental biology JID - 0372762 RN - 9007-49-2 (DNA) RN - G34N38R2N1 (Bromodeoxyuridine) SB - IM MH - Animals MH - Bromodeoxyuridine/metabolism MH - DNA/analysis MH - *DNA Replication MH - Drosophila/cytology/genetics/*growth & development MH - Larva MH - Metamorphosis, Biological MH - Wings, Animal/cytology EDAT- 1987/09/01 00:00 MHDA- 1987/09/01 00:01 CRDT- 1987/09/01 00:00 PHST- 1987/09/01 00:00 [pubmed] PHST- 1987/09/01 00:01 [medline] PHST- 1987/09/01 00:00 [entrez] AID - 0012-1606(87)90436-2 [pii] AID - 10.1016/0012-1606(87)90436-2 [doi] PST - ppublish SO - Dev Biol. 1987 Sep;123(1):145-53. doi: 10.1016/0012-1606(87)90436-2.