PMID- 3627975
OWN - NLM
STAT- MEDLINE
DCOM- 19871005
LR  - 20190501
IS  - 0305-1048 (Print)
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Linking)
VI  - 15
IP  - 15
DP  - 1987 Aug 11
TI  - The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the 
      breast carcinoma cell line MDA-MB231.
PG  - 5963-71
AB  - We have detected amplified human Ki-ras sequences in tumorigenic NIH 3T3 cells 
      transfected with genomic DNA from the human breast carcinoma cell line MDA-MB231. 
      Hybridization of synthetic oligonucleotides specific for human Ki-ras sequences 
      showed a mutation at codon 13. The polymerase chain reaction with Ki-ras specific 
      amplimers revealed a guanosine to adenosine transition at the second position of 
      codon 13, resulting in a substitution of glycine by aspartic acid. The codon 13 
      mutation is also detected in one Ki-ras allele of the MDA-MB231 cell line.
FAU - Kozma, S C
AU  - Kozma SC
FAU - Bogaard, M E
AU  - Bogaard ME
FAU - Buser, K
AU  - Buser K
FAU - Saurer, S M
AU  - Saurer SM
FAU - Bos, J L
AU  - Bos JL
FAU - Groner, B
AU  - Groner B
FAU - Hynes, N E
AU  - Hynes NE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 0 (Codon)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Breast Neoplasms/*genetics
MH  - Cell Line
MH  - *Codon
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - Mice
MH  - *Mutation
MH  - *Proto-Oncogenes
MH  - *RNA, Messenger
MH  - Transfection
PMC - PMC306061
EDAT- 1987/08/11 00:00
MHDA- 1987/08/11 00:01
CRDT- 1987/08/11 00:00
PHST- 1987/08/11 00:00 [pubmed]
PHST- 1987/08/11 00:01 [medline]
PHST- 1987/08/11 00:00 [entrez]
AID - 10.1093/nar/15.15.5963 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 1987 Aug 11;15(15):5963-71. doi: 10.1093/nar/15.15.5963.