PMID- 3767002
OWN - NLM
STAT- MEDLINE
DCOM- 19861030
LR  - 20071114
IS  - 0003-276X (Print)
IS  - 0003-276X (Linking)
VI  - 216
IP  - 1
DP  - 1986 Sep
TI  - Differential distribution of brush cells in the rat lung.
PG  - 49-54
AB  - The distribution of brush cells in the rat lung was studied using electron 
      microscopic morphometry. Samples were taken from six distinctive anatomical 
      regions. Tissue from the trachea, lobar bronchi, terminal bronchioles, first 
      alveolar duct bifurcations, proximal alveolar regions, and the distal alveolar 
      region were isolated and embedded in Epox 812. Aside from the trachea and the 
      lobar bronchi, the other four regions were isolated from embedded tissue using 
      microdissection techniques. Electron micrographs taken from thin sections of 
      these samples were analyzed. It was found that brush cells made up 10% of the 
      volume of epithelium covering the first alveolar duct bifurcation. Approximately 
      2% of the proximal alveolar epithelium, 1.4% of the terminal bronchiolar 
      epithelium, and 3% of the tracheal epithelium were made up of brush cells. No 
      brush-bordered epithelium was found in the lobar bronchi or in the distal 
      alveolar walls. We conclude that brush cells have a distinct spatial location in 
      the lung, being in high concentration in the trachea and in areas where first 
      generation alveolar ducts bifurcate. The highest density was on the bifurcation 
      of the first alveolar ducts, and their density decreased radially from this 
      region.
FAU - Chang, L Y
AU  - Chang LY
FAU - Mercer, R R
AU  - Mercer RR
FAU - Crapo, J D
AU  - Crapo JD
LA  - eng
GR  - 2PO1-HL-31992/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Anat Rec
JT  - The Anatomical record
JID - 0370540
SB  - IM
MH  - Animals
MH  - Bronchi/cytology
MH  - Epithelium/ultrastructure
MH  - Lung/*cytology
MH  - Male
MH  - Microvilli/*ultrastructure
MH  - Pulmonary Alveoli/cytology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Rats, Inbred Strains
MH  - Trachea/cytology
EDAT- 1986/09/01 00:00
MHDA- 1986/09/01 00:01
CRDT- 1986/09/01 00:00
PHST- 1986/09/01 00:00 [pubmed]
PHST- 1986/09/01 00:01 [medline]
PHST- 1986/09/01 00:00 [entrez]
AID - 10.1002/ar.1092160109 [doi]
PST - ppublish
SO  - Anat Rec. 1986 Sep;216(1):49-54. doi: 10.1002/ar.1092160109.