PMID- 3802184 OWN - NLM STAT- MEDLINE DCOM- 19870326 LR - 20191022 IS - 0008-8730 (Print) IS - 0008-8730 (Linking) VI - 19 IP - 6 DP - 1986 Nov TI - Effects of puromycin, cycloheximide and noradrenaline on cell migration within the crypts and on the villi of the small intestine. A model to explain cell movement in both regions. PG - 611-25 AB - The normal process of cell migration, occurring as part of the replacement scheme within the small intestinal epithelium, was investigated extensively. The effects of puromycin, cycloheximide and noradrenaline on the movement of tritiated thymidine [( 3H]TdR) prelabelled crypt or villus cells have been studied. These studies have led to the formulation of a model for the mechanism of cell migration, postulating that the crypts and villi behave as separate units, with regard to cell migration, in addition to their distinct structural and functional properties. It is proposed that crypt cell migration is an active process requiring protein synthesis and protein glycosylation, whilst movement of villus epithelial cells is passive, depending on the continued contraction of smooth muscle cells in the lamina propria. FAU - Kaur, P AU - Kaur P FAU - Potten, C S AU - Potten CS LA - eng PT - Journal Article PL - England TA - Cell Tissue Kinet JT - Cell and tissue kinetics JID - 0174107 RN - 4A6ZS6Q2CL (Puromycin) RN - 98600C0908 (Cycloheximide) RN - X4W3ENH1CV (Norepinephrine) SB - IM MH - Animals MH - Basement Membrane/physiology MH - Cell Movement/drug effects MH - Cycloheximide/*pharmacology MH - Epithelial Cells MH - Epithelium/drug effects MH - Intestinal Mucosa/cytology/*drug effects MH - Intestine, Small/cytology/*drug effects MH - Male MH - Mice MH - Norepinephrine/*pharmacology MH - Puromycin/*pharmacology EDAT- 1986/11/01 00:00 MHDA- 1986/11/01 00:01 CRDT- 1986/11/01 00:00 PHST- 1986/11/01 00:00 [pubmed] PHST- 1986/11/01 00:01 [medline] PHST- 1986/11/01 00:00 [entrez] AID - 10.1111/j.1365-2184.1986.tb00762.x [doi] PST - ppublish SO - Cell Tissue Kinet. 1986 Nov;19(6):611-25. doi: 10.1111/j.1365-2184.1986.tb00762.x.