PMID- 3917858
OWN - NLM
STAT- MEDLINE
DCOM- 19850321
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 40
IP  - 2
DP  - 1985 Feb
TI  - Structure, organization, and somatic rearrangement of T cell gamma genes.
PG  - 259-69
AB  - We present the initial characterization of a novel family of genes that rearrange 
      in T cells, but do not encode either of the defined (alpha/beta) subunits of the 
      clone-specific heterodimer of the T cell receptor. The family comprises at least 
      three variable (V) gene segments, three constant (C) gene segments, and three 
      junction (J) gene segments. In a cloned cytolytic T lymphocyte, 2C, one of each 
      of these fragments has productively rearranged to yield an expressed VJC 
      transcription unit, which shows no evidence for somatic mutation. Short sequences 
      similar to those implicated in immunoglobulin gene and T cell receptor beta chain 
      gene rearrangement flank the V and J segments of this family. The linkage of two 
      of the three V gene segments has been determined: the segments lie approximately 
      2.5 kb apart, and are arranged head-to-head. The inverted arrangement may cast 
      light upon the mechanisms utilized by lymphocytes for gene rearrangement.
FAU - Hayday, A C
AU  - Hayday AC
FAU - Saito, H
AU  - Saito H
FAU - Gillies, S D
AU  - Gillies SD
FAU - Kranz, D M
AU  - Kranz DM
FAU - Tanigawa, G
AU  - Tanigawa G
FAU - Eisen, H N
AU  - Eisen HN
FAU - Tonegawa, S
AU  - Tonegawa S
LA  - eng
SI  - GENBANK/M12829
SI  - GENBANK/M12830
SI  - GENBANK/M12831
SI  - GENBANK/M12832
SI  - GENBANK/M12833
SI  - GENBANK/M12834
SI  - GENBANK/M12835
SI  - GENBANK/M12836
SI  - GENBANK/M12837
SI  - GENBANK/M12838
SI  - GENBANK/M12839
GR  - CA-14051/CA/NCI NIH HHS/United States
GR  - CA-28900-04/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Immunoglobulins)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA/analysis
MH  - *Genes, MHC Class II
MH  - Immunoglobulins/genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Protein Biosynthesis
MH  - Receptors, Antigen, T-Cell/*genetics
MH  - Recombination, Genetic
EDAT- 1985/02/01 00:00
MHDA- 1985/02/01 00:01
CRDT- 1985/02/01 00:00
PHST- 1985/02/01 00:00 [pubmed]
PHST- 1985/02/01 00:01 [medline]
PHST- 1985/02/01 00:00 [entrez]
AID - 0092-8674(85)90140-0 [pii]
AID - 10.1016/0092-8674(85)90140-0 [doi]
PST - ppublish
SO  - Cell. 1985 Feb;40(2):259-69. doi: 10.1016/0092-8674(85)90140-0.