PMID- 3918894
OWN - NLM
STAT- MEDLINE
DCOM- 19850322
LR  - 20220309
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 107
IP  - 2
DP  - 1985 Feb
TI  - Intrinsic growth control in the imaginal primordia of Drosophila, and the 
      autonomous action of a lethal mutation causing overgrowth.
PG  - 355-63
AB  - Cell proliferation in Drosophila imaginal discs appears to be regulated by a 
      disc-intrinsic mechanism involving local cell interactions that also control the 
      formation of patterns of differentiation. This growth-control mechanism breaks 
      down in animals homozygous for the mutation lethal (2) giant discs (l(2)gd) which 
      remain as larvae for up to 9 days longer than normal. During this time cell 
      proliferation continues in the imaginal discs as well as in the imaginal rings 
      for the salivary glands, foregut, and hindgut, so that these tissues become 
      greatly overgrown. When wild-type wing discs from mid-third instar larvae were 
      removed and cultured for up to 28 days in wild-type female adult hosts, they grew 
      and terminated growth at a cell number close to that which would be attained in 
      situ by the time of pupariation. On the other hand, wing discs from l(2)gd 
      homozygotes grew rapidly and continuously when cultivated in wild-type hosts, 
      reached an enormous size, and acquired abnormal folding patterns. Overgrowth of 
      mutant imaginal rings also continued during culture of these tissues in wild-type 
      hosts. We conclude that overgrowth in this mutant is due to an autonomous defect 
      in the imaginal primordia, which requires an extended larval period for its 
      expression in situ.
FAU - Bryant, P J
AU  - Bryant PJ
FAU - Levinson, P
AU  - Levinson P
LA  - eng
GR  - HD06082/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
SB  - IM
MH  - Animals
MH  - Drosophila melanogaster/genetics/*growth & development
MH  - Genes, Lethal
MH  - Intestines/growth & development
MH  - Larva/anatomy & histology/cytology
MH  - Mutation
MH  - Salivary Glands/growth & development
MH  - Wings, Animal/growth & development
EDAT- 1985/02/01 00:00
MHDA- 1985/02/01 00:01
CRDT- 1985/02/01 00:00
PHST- 1985/02/01 00:00 [pubmed]
PHST- 1985/02/01 00:01 [medline]
PHST- 1985/02/01 00:00 [entrez]
AID - 0012-1606(85)90317-3 [pii]
AID - 10.1016/0012-1606(85)90317-3 [doi]
PST - ppublish
SO  - Dev Biol. 1985 Feb;107(2):355-63. doi: 10.1016/0012-1606(85)90317-3.