PMID- 4078630
OWN - NLM
STAT- MEDLINE
DCOM- 19860207
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 5
IP  - 12
DP  - 1985 Dec
TI  - Identification of major cell classes in the developing mammalian nervous system.
PG  - 3310-28
AB  - A major difficulty in studying early developmental processes and testing 
      hypotheses of possible cellular mechanisms of development has been the inability 
      to reproducibly identify specific cell types. We have generated monoclonal 
      antibodies that distinguish among major cell types present during mammalian 
      neurogenesis. These antibodies have been used to analyze the development of 
      cellular organization in the early nervous system. Monoclonal antibody Rat-401 
      identifies a transient radial glial cell in the embryonic rat central nervous 
      system (CNS) that is temporally and spatially suited to guide neuronal migration. 
      Rat-401 also identifies a peripheral non-neuronal cell that may establish axon 
      routes from the CNS to the periphery. Monoclonal antibody Rat-202 recognizes an 
      antigen present in early axons, their growth cones, and filopodia, and has 
      allowed us to follow early axons and observe the structures they contact. Two 
      other antibodies that recognize axons demonstrate antigenically distinct phases 
      in axon development. In addition, we report a marker for another cell class 
      present in the developing nervous system, the endothelial cells that give rise to 
      the CNS vasculature.
FAU - Hockfield, S
AU  - Hockfield S
FAU - McKay, R D
AU  - McKay RD
LA  - eng
GR  - NS 17556/NS/NINDS NIH HHS/United States
GR  - NS 18040/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Lectins)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Axons/physiology/ultrastructure
MH  - Blood Vessels/embryology
MH  - Cell Differentiation
MH  - Central Nervous System/cytology/*embryology/ultrastructure
MH  - Lectins
MH  - Neuroglia/cytology
MH  - Neurons/*classification/ultrastructure
MH  - Rats/embryology
MH  - Spinal Nerve Roots/cytology/embryology
PMC - PMC6565218
EDAT- 1985/12/01 00:00
MHDA- 1985/12/01 00:01
PMCR- 1986/06/01
CRDT- 1985/12/01 00:00
PHST- 1985/12/01 00:00 [pubmed]
PHST- 1985/12/01 00:01 [medline]
PHST- 1985/12/01 00:00 [entrez]
PHST- 1986/06/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.05-12-03310.1985 [doi]
PST - ppublish
SO  - J Neurosci. 1985 Dec;5(12):3310-28. doi: 10.1523/JNEUROSCI.05-12-03310.1985.