PMID- 4561027
OWN - NLM
STAT- MEDLINE
DCOM- 19721116
LR  - 20240109
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 26
IP  - 4
DP  - 1972 Aug
TI  - Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue 
      kinetics.
PG  - 239-57
AB  - The term apoptosis is proposed for a hitherto little recognized mechanism of 
      controlled cell deletion, which appears to play a complementary but opposite role 
      to mitosis in the regulation of animal cell populations. Its morphological 
      features suggest that it is an active, inherently programmed phenomenon, and it 
      has been shown that it can be initiated or inhibited by a variety of 
      environmental stimuli, both physiological and pathological.The structural changes 
      take place in two discrete stages. The first comprises nuclear and cytoplasmic 
      condensation and breaking up of the cell into a number of membrane-bound, 
      ultrastructurally well-preserved fragments. In the second stage these apoptotic 
      bodies are shed from epithelial-lined surfaces or are taken up by other cells, 
      where they undergo a series of changes resembling in vitro autolysis within 
      phagosomes, and are rapidly degraded by lysosomal enzymes derived from the 
      ingesting cells.Apoptosis seems to be involved in cell turnover in many healthy 
      adult tissues and is responsible for focal elimination of cells during normal 
      embryonic development. It occurs spontaneously in untreated malignant neoplasms, 
      and participates in at least some types of therapeutically induced tumour 
      regression. It is implicated in both physiological involution and atrophy of 
      various tissues and organs. It can also be triggered by noxious agents, both in 
      the embryo and adult animal.
FAU - Kerr, J F
AU  - Kerr JF
FAU - Wyllie, A H
AU  - Wyllie AH
FAU - Currie, A R
AU  - Currie AR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
SB  - IM
CIN - Exp Dermatol. 2015 Feb;24(2):99-100. PMID: 25470131
MH  - Adrenal Glands/pathology
MH  - Animals
MH  - Atrophy/pathology
MH  - Autolysis
MH  - Carcinoma, Squamous Cell/pathology
MH  - *Cell Division
MH  - *Cells
MH  - Culture Techniques
MH  - Histiocytes
MH  - Homeostasis
MH  - Humans
MH  - Kinetics
MH  - Mammary Neoplasms, Experimental/pathology
MH  - Mesoderm/pathology
MH  - Microscopy, Electron
MH  - Mitosis
MH  - Phagocytosis
MH  - Rats
PMC - PMC2008650
EDAT- 1972/08/01 00:00
MHDA- 1972/08/01 00:01
CRDT- 1972/08/01 00:00
PHST- 1972/08/01 00:00 [pubmed]
PHST- 1972/08/01 00:01 [medline]
PHST- 1972/08/01 00:00 [entrez]
AID - 10.1038/bjc.1972.33 [doi]
PST - ppublish
SO  - Br J Cancer. 1972 Aug;26(4):239-57. doi: 10.1038/bjc.1972.33.