PMID- 6093980
OWN - NLM
STAT- MEDLINE
DCOM- 19841227
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 54
IP  - 11
DP  - 1984 Dec 1
TI  - Selective targeting of anti-cancer drug and simultaneous image enhancement in 
      solid tumors by arterially administered lipid contrast medium.
PG  - 2367-74
AB  - Twenty-four patients with various solid tumors including metastatic liver cancer 
      and cancer of the lung, gallbladder, and pancreas were treated with a lipophilic 
      macromolecular drug, copoly(styrene-maleic acid) conjugated neocarzinostatin 
      (SMANCS). The drug was dissolved in a lipid contrast medium Lipiodol and 
      administered by catheterizing the respective feeding arteries under x-ray 
      monitoring. The advantages of this therapy include: (1) selective deposition of 
      Lipiodol with the anti-cancer drug in the target tumor, (2) a pronounced and 
      long-lasting anti-cancer effect, (3) enhanced visualization of the tumor on x-ray 
      examinations for a prolonged period which also facilitated the long-term 
      follow-up, (4) semiquantitative evaluation of the dosage regimen by x-ray 
      examination before further administration, (5) general applicability due to 
      procedural simplicity, and (6) little side effect. Since the amount of Lipiodol 
      and SMANCS used per administration for a patient (1.0-5.0 ml; 1.0-5.0 mg) was far 
      less than the anticipated toxicity (LD50 of Lipiodol = 95 ml/60 kg, dog, 
      intravenously; and that of SMANCS = 3.4 mg/kg, mouse, IV), no deleterious effects 
      to such critical organs as the brain, heart, lung, liver, or kidneys were 
      observed upon radiologic and general clinical examination.
FAU - Konno, T
AU  - Konno T
FAU - Maeda, H
AU  - Maeda H
FAU - Iwai, K
AU  - Iwai K
FAU - Maki, S
AU  - Maki S
FAU - Tashiro, S
AU  - Tashiro S
FAU - Uchida, M
AU  - Uchida M
FAU - Miyauchi, Y
AU  - Miyauchi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Contrast Media)
RN  - 0 (Maleic Anhydrides)
RN  - 0 (Polystyrenes)
RN  - 0 (poly(maleic acid-styrene)neocarzinostatin)
RN  - 8001-40-9 (Iodized Oil)
RN  - 9014-02-2 (Zinostatin)
SB  - IM
MH  - Adenocarcinoma/diagnostic imaging/*drug therapy
MH  - Aged
MH  - Antibiotics, Antineoplastic/*therapeutic use
MH  - Carcinoma, Squamous Cell/diagnostic imaging/drug therapy
MH  - Contrast Media/*administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Gastrointestinal Neoplasms/diagnostic imaging/*drug therapy
MH  - Humans
MH  - Iodized Oil/*administration & dosage
MH  - Liver Neoplasms/diagnostic imaging/drug therapy/secondary
MH  - Male
MH  - *Maleic Anhydrides
MH  - Middle Aged
MH  - Polystyrenes/*therapeutic use
MH  - Radiography
MH  - Zinostatin/analogs & derivatives/*therapeutic use
EDAT- 1984/12/01 00:00
MHDA- 1984/12/01 00:01
CRDT- 1984/12/01 00:00
PHST- 1984/12/01 00:00 [pubmed]
PHST- 1984/12/01 00:01 [medline]
PHST- 1984/12/01 00:00 [entrez]
AID - 10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f [doi]
PST - ppublish
SO  - Cancer. 1984 Dec 1;54(11):2367-74. doi: 
      10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f.