PMID- 6256757
OWN - NLM
STAT- MEDLINE
DCOM- 19810324
LR  - 20220330
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 77
IP  - 11
DP  - 1980 Nov
TI  - Maternal inheritance of human mitochondrial DNA.
PG  - 6715-9
AB  - Human mitochondrial DNA was obtained from peripheral blood platelets donated by 
      the members of several independent families. The samples were screened for 
      nucleotide sequence polymorphisms between individuals within these families. In 
      each family in which we were able to detect a distinctly different restriction 
      endonuclease cleavage pattern between the parents, the progeny exhibited the 
      maternal cleavage pattern. Informative polymorphisms were detected for Hae II 
      (PuGCGCPy) in a three-generation family composed of 33 members, for HincII 
      (GTPyPuAC) in a two-generation family composed of four members, and for Hae 
      III(GGCC) in a two-generation family composed of four members. The Hae II 
      polymorphism was analyzed through all three generations in both the maternal and 
      paternal lines. The results of this study demonstrate that human mitochondrial 
      DNA is maternally inherited. The techniques described for using peripheral blood 
      platelets as a source of human mitochondrial DNA represent a convenient way to 
      obtain data on mitochondrial DNA variation in both individuals and populations.
FAU - Giles, R E
AU  - Giles RE
FAU - Blanc, H
AU  - Blanc H
FAU - Cann, H M
AU  - Cann HM
FAU - Wallace, D C
AU  - Wallace DC
LA  - eng
GR  - 5T32 CA 09302-03/CA/NCI NIH HHS/United States
GR  - GM 24285/GM/NIGMS NIH HHS/United States
GR  - GM 28428/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA, Mitochondrial)
RN  - EC 3.1.21.- (DNA Restriction Enzymes)
SB  - IM
MH  - Blood Platelets/ultrastructure
MH  - DNA Restriction Enzymes
MH  - DNA, Mitochondrial/*genetics
MH  - *Genetics, Medical
MH  - Humans
MH  - Pedigree
MH  - Polymorphism, Genetic
PMC - PMC350359
EDAT- 1980/11/01 00:00
MHDA- 1980/11/01 00:01
PMCR- 1981/05/01
CRDT- 1980/11/01 00:00
PHST- 1980/11/01 00:00 [pubmed]
PHST- 1980/11/01 00:01 [medline]
PHST- 1980/11/01 00:00 [entrez]
PHST- 1981/05/01 00:00 [pmc-release]
AID - 10.1073/pnas.77.11.6715 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1980 Nov;77(11):6715-9. doi: 10.1073/pnas.77.11.6715.