PMID- 6283357 OWN - NLM STAT- MEDLINE DCOM- 19820807 LR - 20190617 IS - 0028-0836 (Print) IS - 0028-0836 (Linking) VI - 297 IP - 5866 DP - 1982 Jun 10 TI - Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. PG - 474-8 AB - Examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma (EJ) oncogene is homologous to the Harvey sarcoma virus oncogene (ras). Structural analysis limits the region of homology to a 3.0-kilobase SacI fragment of the EJ oncogene. Both EJ and ras DNA probes detect similar transcripts in transfectants derived from bladder carcinoma cell lines. FAU - Parada, L F AU - Parada LF FAU - Tabin, C J AU - Tabin CJ FAU - Shih, C AU - Shih C FAU - Weinberg, R A AU - Weinberg RA LA - eng GR - CA17537/CA/NCI NIH HHS/United States GR - CA26717/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - England TA - Nature JT - Nature JID - 0410462 RN - 0 (DNA, Neoplasm) RN - 0 (DNA, Viral) RN - EC 3.1.21.- (DNA Restriction Enzymes) SB - IM MH - Animals MH - Base Sequence MH - Cell Line MH - Cell Transformation, Neoplastic MH - DNA Restriction Enzymes MH - DNA, Neoplasm/*genetics MH - DNA, Viral/*genetics MH - *Genes MH - *Genes, Viral MH - Humans MH - Mice MH - Nucleic Acid Hybridization MH - Oncogenic Viruses/*genetics MH - Sarcoma Viruses, Murine/*genetics MH - Species Specificity MH - Transcription, Genetic MH - Urinary Bladder Neoplasms/*genetics EDAT- 1982/06/10 00:00 MHDA- 1982/06/10 00:01 CRDT- 1982/06/10 00:00 PHST- 1982/06/10 00:00 [pubmed] PHST- 1982/06/10 00:01 [medline] PHST- 1982/06/10 00:00 [entrez] AID - 10.1038/297474a0 [doi] PST - ppublish SO - Nature. 1982 Jun 10;297(5866):474-8. doi: 10.1038/297474a0.