PMID- 6310411
OWN - NLM
STAT- MEDLINE
DCOM- 19831021
LR  - 20200327
IS  - 0028-0836 (Print)
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 305
IP  - 5930
DP  - 1983 Sep 8-14
TI  - Adoptive transfer of EAE-like lesions from rats with coronavirus-induced 
      demyelinating encephalomyelitis.
PG  - 150-3
AB  - Viruses have been found to induce inflammatory demyelinating lesions in central 
      nervous system (CNS) tissue of both animal and man, either by natural infections 
      or after vaccination. At least two different pathogenic mechanisms have been 
      proposed for these changes, a cytopathic viral infection of oligodendroglia cells 
      with subsequent cell death, and a host immune reaction against virus and brain 
      antigens. We now report the occurrence of cell-mediated immune reactions against 
      basic myelin proteins in the course of coronavirus infections in Lewis rats. 
      Infection of rats with the murine coronavirus JHM leads to demyelinating 
      encephalomyelitis developing several weeks to months postinfection. Lymphocytes 
      from these diseased Lewis rats can be restimulated with basic myelin protein 
      (BMP) and adoptive transfer of these cells leads to lesions resembling those of 
      experimental allergic encephalomyelitis (EAE) in recipients, which can be 
      accompanied by a mild clinical disease. This model demonstrates that a virus 
      infection in CNS tissue is capable of initiating an autoimmune response which may 
      be of pathogenic importance.
FAU - Watanabe, R
AU  - Watanabe R
FAU - Wege, H
AU  - Wege H
FAU - ter Meulen, V
AU  - ter Meulen V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - Animals
MH  - Coronaviridae Infections/immunology/*physiopathology
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/*physiopathology
MH  - Immunity, Cellular
MH  - Lymphocytes/immunology
MH  - Rats
PMC - PMC7094959
EDAT- 1983/09/08 00:00
MHDA- 1983/09/08 00:01
PMCR- 2020/03/25
CRDT- 1983/09/08 00:00
PHST- 1983/09/08 00:00 [pubmed]
PHST- 1983/09/08 00:01 [medline]
PHST- 1983/09/08 00:00 [entrez]
PHST- 2020/03/25 00:00 [pmc-release]
AID - BF305150a0 [pii]
AID - 10.1038/305150a0 [doi]
PST - ppublish
SO  - Nature. 1983 Sep 8-14;305(5930):150-3. doi: 10.1038/305150a0.