PMID- 6318122
OWN - NLM
STAT- MEDLINE
DCOM- 19840223
LR  - 20230108
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 307
IP  - 5947
DP  - 1984 Jan 12-18
TI  - Mode of proviral activation of a putative mammary oncogene (int-1) on mouse 
      chromosome 15.
PG  - 131-6
AB  - Most mammary carcinomas induced in C3H mice by the mouse mammary tumour virus 
      (MMTV) bear a new proviral insertion within a highly conserved locus on 
      chromosome 15 called int-1. A transcriptional unit within this locus is inactive 
      in all tested normal tissues but expressed at low levels in mammary tumours with 
      proviral insertions positioned on either the 5' and 3' sides of the gene. 
      Transcription of the proviruses proceeds away from int-1; thus an indirect 
      mechanism appears to activate expression of this putative oncogene.
FAU - Nusse, R
AU  - Nusse R
FAU - van Ooyen, A
AU  - van Ooyen A
FAU - Cox, D
AU  - Cox D
FAU - Fung, Y K
AU  - Fung YK
FAU - Varmus, H
AU  - Varmus H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Biological Evolution
MH  - *Cell Transformation, Viral
MH  - Chromosome Mapping
MH  - Female
MH  - Gene Expression Regulation
MH  - Mammary Neoplasms, Experimental/genetics
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mutation
MH  - *Oncogenes
MH  - RNA, Messenger/genetics
MH  - Transcription, Genetic
EDAT- 1984/01/12 00:00
MHDA- 1984/01/12 00:01
CRDT- 1984/01/12 00:00
PHST- 1984/01/12 00:00 [pubmed]
PHST- 1984/01/12 00:01 [medline]
PHST- 1984/01/12 00:00 [entrez]
AID - 10.1038/307131a0 [doi]
PST - ppublish
SO  - Nature. 1984 Jan 12-18;307(5947):131-6. doi: 10.1038/307131a0.